| Literature DB >> 25575304 |
Anna A Krasilnikova1, Michael A Shestopalov2, Konstantin A Brylev3, Irina A Kirilova4, Olga P Khripko5, Kristina E Zubareva6, Yuri I Khripko5, Valentina T Podorognaya4, Lidiya V Shestopalova1, Vladimir E Fedorov3, Yuri V Mironov3.
Abstract
Investigation of new X-ray contrast media for radiography is an important field of science since discovering of X-rays in 1895. Despite the wide diversity of available X-ray contrast media the toxicity, especially nephrotoxicity, is still a big problem to be solved. The octahedral metal-cluster complexes of the general formula [{M6Q8}L6] can be considered as quite promising candidates for the role of new radiocontrast media due to the high local concentration of heavy elements, high tuning ability of ligand environment and low toxicity. To exemplify this, the X-ray computed tomography experiments for the first time were carried out on some octahedral cluster complexes of molybdenum and rhenium. Based on the obtained data it was proposed to investigate the toxicological proprieties of cluster complex Na2H8[{Re6Se8}(P(CH2CH2CONH2)(CH2CH2COO)2)6]. Observed low cytotoxic and acute toxic effects along with rapid renal excretion of the cluster complex evidence its perspective as an X-ray contrast media for radiography.Entities:
Keywords: Octahedral metal clusters; X-ray computed tomography; X-ray contrast media
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Year: 2014 PMID： 25575304 DOI： 10.1016/j.jinorgbio.2014.12.016
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155