Jinkyung Cho1, Min-Kyoo Shin, Donghyun Kim, Inhwan Lee, Shinuk Kim, Hyunsik Kang. 1. 1College of Sport Science, Sungkyunkwan University, Suwon, REPUBLIC OF KOREA; 2Department of Biological Sciences, Sungkyunkwan University, Suwon, REPUBLIC OF KOREA; and 3College of Engineering, Sangmyung University, Cheonan, REPUBLIC OF KOREA.
Abstract
PURPOSE: This study investigated the effect of treadmill running on cognitive declines in the early and advanced stages of Alzheimer disease (AD) in 3xTg-AD mice. METHODS: At 4 months of age, 3xTg-AD mice (N = 24) were assigned to control (AD + CON, n = 12) or exercise (AD + EX, n = 12) group. At 24 months of age, 3xTg-AD mice (N = 16) were assigned to AD + CON (n = 8) or AD + EX (n = 8) group. The AD + EX mice were subjected to treadmill running for 12 wk. At each pathological stage, the background strain mice were included as wild-type control (WT + CON, n = 8-12). RESULTS: At the early stage of AD, 3xTg-AD mice had impaired short- and long-term memory based on Morris water maze along with higher cortical Aβ deposition, higher hippocampal and cortical tau pathology, and lower hippocampal and cortical PSD-95 and synaptophysin. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the tau pathology along with suppression of the decreased PSD-95 and synaptophysin in the hippocampus and cortex. At the advanced stage of AD, 3xTg-AD mice had impaired short- and long-term memory along with higher levels of Aβ deposition, soluble Aβ1-40 and Aβ1-42, tau pathology, and lower levels of brain-derived neurotrophic factor, PSD-95, and synaptophysin in the hippocampus and cortex. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the Aβ and tau pathology along with suppression of the decreased synaptic proteins and brain-derived neurotrophic factor in the hippocampus and cortex. CONCLUSIONS: The current findings suggest that treadmill running provides a nonpharmacological means to combat cognitive declines due to AD pathology.
PURPOSE: This study investigated the effect of treadmill running on cognitive declines in the early and advanced stages of Alzheimer disease (AD) in 3xTg-AD mice. METHODS: At 4 months of age, 3xTg-AD mice (N = 24) were assigned to control (AD + CON, n = 12) or exercise (AD + EX, n = 12) group. At 24 months of age, 3xTg-AD mice (N = 16) were assigned to AD + CON (n = 8) or AD + EX (n = 8) group. The AD + EX mice were subjected to treadmill running for 12 wk. At each pathological stage, the background strain mice were included as wild-type control (WT + CON, n = 8-12). RESULTS: At the early stage of AD, 3xTg-AD mice had impaired short- and long-term memory based on Morris water maze along with higher cortical Aβ deposition, higher hippocampal and cortical tau pathology, and lower hippocampal and cortical PSD-95 and synaptophysin. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the tau pathology along with suppression of the decreased PSD-95 and synaptophysin in the hippocampus and cortex. At the advanced stage of AD, 3xTg-AD mice had impaired short- and long-term memory along with higher levels of Aβ deposition, soluble Aβ1-40 and Aβ1-42, tau pathology, and lower levels of brain-derived neurotrophic factor, PSD-95, and synaptophysin in the hippocampus and cortex. A 12-wk treadmill running reversed the impaired cognitive declines and significantly improved the Aβ and tau pathology along with suppression of the decreased synaptic proteins and brain-derived neurotrophic factor in the hippocampus and cortex. CONCLUSIONS: The current findings suggest that treadmill running provides a nonpharmacological means to combat cognitive declines due to AD pathology.
Authors: Michelle W Voss; Carmen Soto; Seungwoo Yoo; Matthew Sodoma; Carmen Vivar; Henriette van Praag Journal: Trends Cogn Sci Date: 2019-02-16 Impact factor: 20.229
Authors: Se Hoon Choi; Enjana Bylykbashi; Zena K Chatila; Star W Lee; Benjamin Pulli; Gregory D Clemenson; Eunhee Kim; Alexander Rompala; Mary K Oram; Caroline Asselin; Jenna Aronson; Can Zhang; Sean J Miller; Andrea Lesinski; John W Chen; Doo Yeon Kim; Henriette van Praag; Bruce M Spiegelman; Fred H Gage; Rudolph E Tanzi Journal: Science Date: 2018-09-07 Impact factor: 47.728
Authors: Jennifer M Petrosino; Valerie J Heiss; Santosh K Maurya; Anuradha Kalyanasundaram; Muthu Periasamy; Richard A LaFountain; Jacob M Wilson; Orlando P Simonetti; Ouliana Ziouzenkova Journal: PLoS One Date: 2016-02-09 Impact factor: 3.240