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Literature DB >> 25574615

Amgen's angiopoietin blocker fails in ovarian cancer.

Cormac Sheridan.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2015 PMID： 25574615 DOI： 10.1038/nbt0115-5

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

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7 in total

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2. Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.

Authors: Christopher Daly; Alexandra Eichten; Carla Castanaro; Elizabeth Pasnikowski; Alexander Adler; Alshad S Lalani; Nicholas Papadopoulos; Alastair H Kyle; Andrew I Minchinton; George D Yancopoulos; Gavin Thurston
Journal: Cancer Res Date: 2012-11-13 Impact factor: 12.701

Review 3. Molecular mechanisms and clinical applications of angiogenesis.

Authors: Peter Carmeliet; Rakesh K Jain
Journal: Nature Date: 2011-05-19 Impact factor: 49.962

4. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.

Authors: Gabriela D'Amico; Emilia A Korhonen; Andrey Anisimov; Georgia Zarkada; Tanja Holopainen; René Hägerling; Friedemann Kiefer; Lauri Eklund; Raija Sormunen; Harri Elamaa; Rolf A Brekken; Ralf H Adams; Gou Young Koh; Pipsa Saharinen; Kari Alitalo
Journal: J Clin Invest Date: 2014-01-16 Impact factor: 14.808

5. Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.

Authors: Kshitij Srivastava; Junhao Hu; Claudia Korn; Soniya Savant; Martin Teichert; Stephanie S Kapel; Manfred Jugold; Eva Besemfelder; Markus Thomas; Manolis Pasparakis; Hellmut G Augustin
Journal: Cancer Cell Date: 2014-12-08 Impact factor: 31.743

6. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.

Authors: Yvonne Kienast; Christian Klein; Werner Scheuer; Romi Raemsch; Erica Lorenzon; Dirk Bernicke; Frank Herting; Sidney Yu; Huynh Hung The; Laurent Martarello; Christian Gassner; Kay-Gunnar Stubenrauch; Kate Munro; Hellmut G Augustin; Markus Thomas
Journal: Clin Cancer Res Date: 2013-10-04 Impact factor: 12.531

7. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth.

Authors: Patrick Nasarre; Markus Thomas; Karoline Kruse; Iris Helfrich; Vivien Wolter; Carleen Deppermann; Dirk Schadendorf; Gavin Thurston; Ulrike Fiedler; Hellmut G Augustin
Journal: Cancer Res Date: 2009-02-10 Impact factor: 12.701

7 in total

8 in total

1. Gene therapy 'cure' for blindness wanes.

Authors: Anna Azvolinsky
Journal: Nat Biotechnol Date: 2015-07 Impact factor: 54.908

Review 2. Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy.

Authors: Lars M Schiffmann; Christiane J Bruns; Thomas Schmidt
Journal: Front Oncol Date: 2022-05-19 Impact factor: 5.738

Review 3. Preclinical mouse solid tumour models: status quo, challenges and perspectives.

Authors: Nicolas Gengenbacher; Mahak Singhal; Hellmut G Augustin
Journal: Nat Rev Cancer Date: 2017-10-27 Impact factor: 60.716

4. Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer.

Authors: Florence T H Wu; Marta Paez-Ribes; Ping Xu; Shan Man; Elena Bogdanovic; Gavin Thurston; Robert S Kerbel
Journal: Sci Rep Date: 2016-11-14 Impact factor: 4.379

5. Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers.

Authors: Florence T H Wu; Shan Man; Ping Xu; Annabelle Chow; Marta Paez-Ribes; Christina R Lee; Steven R Pirie-Shepherd; Urban Emmenegger; Robert S Kerbel
Journal: Cancer Res Date: 2016-09-20 Impact factor: 12.701