Literature DB >> 25574525

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling.

Zhiqin Deng1, Lianling Yu, Wenqiang Cao, Wenjie Zheng, Tianfeng Chen.   

Abstract

A novel selenium-containing ruthenium complex Ru(phtpy)(phenSe)Cl(ClO4) (phtpy = 4-phenyl-2,2':6',2''-terpyridine, phenSe = 2-selenicimidazole[4,5-f]1,10-phenanthroline) has been synthesized and found be able to enhance radiation-induced DNA damage through superoxide overproduction, which leads to G2/M arrest and apoptosis in cancer cells by activating ROS-mediated pathways.

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Year:  2015        PMID： 25574525     DOI： 10.1039/c4cc07926d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  Ruthenium(ii)-arene complexes as anti-metastatic agents, and related techniques.

Authors:  Chanchal Sonkar; Sayantan Sarkar; Suman Mukhopadhyay
Journal:  RSC Med Chem       Date:  2021-09-15

2.  Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.

Authors:  R Carter; A Westhorpe; M J Romero; A Habtemariam; C R Gallevo; Y Bark; N Menezes; P J Sadler; R A Sharma
Journal:  Sci Rep       Date:  2016-02-12       Impact factor: 4.379

3.  A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.

Authors:  Martin R Gill; Siti Norain Harun; Swagata Halder; Ramon A Boghozian; Kristijan Ramadan; Haslina Ahmad; Katherine A Vallis
Journal:  Sci Rep       Date:  2016-08-25       Impact factor: 4.379

4.  A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator.

Authors:  Martin R Gill; Paul J Jarman; Swagata Halder; Michael G Walker; Hiwa K Saeed; Jim A Thomas; Carl Smythe; Kristijan Ramadan; Katherine A Vallis
Journal:  Chem Sci       Date:  2017-11-16       Impact factor: 9.969

5.  Phoenix Dan Cong Tea: An Oolong Tea variety with promising antioxidant and in vitro anticancer activity.

Authors:  Xiaobin Zhang; Zhenhuan Song; Yuanyuan You; Xiaoling Li; Tianfeng Chen
Journal:  Food Nutr Res       Date:  2018-11-13       Impact factor: 3.894

6.  Molecular Mechanism for Selective Cytotoxicity towards Cancer Cells of Diselenide-Containing Paclitaxel Nanoparticles.

Authors:  Jing Li; Yue Gu; Wei Zhang; Cui-Yu Bao; Cai-Rong Li; Jing-Yi Zhang; Tao Liu; Shuai Li; Jia-Xi Huang; Zhi-Gang Xie; Shu-Cheng Hua; Ying Wan
Journal:  Int J Biol Sci       Date:  2019-07-03       Impact factor: 6.580

7.  RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation.

Authors:  Wenjian Liu; Jing Su; Qiang Shi; Jinlei Wang; Xiao Chen; Shizhong Zhang; Mengkao Li; Jie Cui; Cundong Fan; Beibei Sun; Guojun Wang
Journal:  Front Bioeng Biotechnol       Date:  2021-12-23

8.  Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage.

Authors:  Yuyang Zhou; Ying Xu; Lunjie Lu; Jingyang Ni; Jihua Nie; Jianping Cao; Yang Jiao; Qi Zhang
Journal:  Theranostics       Date:  2019-09-18       Impact factor: 11.556
  8 in total

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