| Literature DB >> 25574524 |
Gary W Black1, Nicola L Brown, Justin J B Perry, P David Randall, Graeme Turnbull, Meng Zhang.
Abstract
Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and hydrolysis of 38 nitrile substrates by 23 nitrilases as cell-free extracts has been shown.Entities:
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Year: 2015 PMID： 25574524 DOI： 10.1039/c4cc06021k
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222