Literature DB >> 25574432

Ex vivo 4D visualization of aortic valve dynamics in a murine model with optical coherence tomography.

Christian Schnabel1, Anett Jannasch2, Saskia Faak3, Thomas Waldow4, Edmund Koch5.   

Abstract

The heart and its mechanical components, especially the heart valves and leaflets, are under enormous strain and undergo fatigue, which impinge upon cardiac output. The knowledge about changes of the dynamic behavior and the possibility of early stage diagnosis could lead to the development of new treatment strategies. Animal models are suited for the development and evaluation of new experimental approaches and therefor innovative imaging techniques are necessary. In this study, we present the time resolved visualization of healthy and calcified aortic valves in an ex vivo artificially stimulated heart model with 4D optical coherence tomography and high-speed video microscopy.

Entities:  

Keywords:  (000.1430) Biology and medicine; (170.2655) Functional monitoring and imaging; (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.6935) Tissue characterization

Year:  2014        PMID： 25574432      PMCID： PMC4285599          DOI： 10.1364/BOE.5.004201

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  26 in total

1.  The elastic properties of valve interstitial cells undergoing pathological differentiation.

Authors:  Kristine Wyss; Cindy Y Y Yip; Zahra Mirzaei; Xiaofan Jin; Jan-Hung Chen; Craig A Simmons
Journal:  J Biomech       Date:  2011-12-19       Impact factor: 2.712

2.  Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.

Authors:  Elena Aikawa; Matthias Nahrendorf; David Sosnovik; Vincent M Lok; Farouc A Jaffer; Masanori Aikawa; Ralph Weissleder
Journal:  Circulation       Date:  2007-01-15       Impact factor: 29.690

3.  4D embryonic cardiography using gated optical coherence tomography.

Authors:  M W Jenkins; F Rothenberg; D Roy; V P Nikolski; Z Hu; M Watanabe; D L Wilson; I R Efimov; A M Rollins
Journal:  Opt Express       Date:  2006-01-23       Impact factor: 3.894

Review 4.  Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues.

Authors:  Jan-Hung Chen; Craig A Simmons
Journal:  Circ Res       Date:  2011-06-10       Impact factor: 17.367

5.  Expression of smooth muscle cell markers and co-activators in calcified aortic valves.

Authors:  Najma Latif; Padmini Sarathchandra; Adrian H Chester; Magdi H Yacoub
Journal:  Eur Heart J       Date:  2014-01-12       Impact factor: 29.983

6.  Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast.

Authors:  R H Messier; B L Bass; H M Aly; J L Jones; P W Domkowski; R B Wallace; R A Hopkins
Journal:  J Surg Res       Date:  1994-07       Impact factor: 2.192

Review 7.  Cellular mechanisms of aortic valve calcification.

Authors:  Jane A Leopold
Journal:  Circ Cardiovasc Interv       Date:  2012-08-01       Impact factor: 6.546

Review 8.  [Indication and timing of heart valve surgery - summery of the European guidelines].

Authors:  Simon H Sündermann; Diana Reser; Martin Czerny; Volkmar Falk
Journal:  Praxis (Bern 1994)       Date:  2014-04-09

9.  4D reconstruction of the beating embryonic heart from two orthogonal sets of parallel optical coherence tomography slice-sequences.

Authors:  Sandeep Bhat; Irina V Larina; Kirill V Larin; Mary E Dickinson; Michael Liebling
Journal:  IEEE Trans Med Imaging       Date:  2012-12-04       Impact factor: 10.048

10.  Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.

Authors:  Elena Aikawa; Peter Whittaker; Mark Farber; Karen Mendelson; Robert F Padera; Masanori Aikawa; Frederick J Schoen
Journal:  Circulation       Date:  2006-03-14       Impact factor: 29.690
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  2 in total

1.  Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila.

Authors:  J P Joos; A R Saadatmand; C Schnabel; I Viktorinová; T Brand; M Kramer; S Nattel; D Dobrev; P Tomancak; J Backs; P Kleinbongard; G Heusch; K Lorenz; E Koch; S Weber; A El-Armouche
Journal:  Sci Rep       Date:  2018-02-13       Impact factor: 4.379

2.  Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoE-/- mice.

Authors:  Anett Jannasch; Christian Schnabel; Roberta Galli; Saskia Faak; Petra Büttner; Claudia Dittfeld; Sems Malte Tugtekin; Edmund Koch; Klaus Matschke
Journal:  Sci Rep       Date:  2021-03-12       Impact factor: 4.379
  2 in total

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