Literature DB >> 2557384

Complement-independent neutralising monoclonal antibody with differential reactivity for strains of human cytomegalovirus.

C Baboonian1, K Blake, J C Booth, C N Wiblin.   

Abstract

A mouse monoclonal antibody with complement-independent neutralising activity against cytomegalovirus (CMV) and reactive with the 86 kilodalton (kDa) viral glycoprotein H is described. Neutralisation tests against a range of different strains of CMV showed significant crossreactivity, but clear differences were evident between the two prototype viruses AD169 and Davis, and particularly between AD169 and several low-passage recent clinical isolates; CMV present in urine was neutralised weakly if at all.

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Year:  1989        PMID： 2557384     DOI： 10.1002/jmv.1890290212

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  6 in total

1.  Neutralizing monoclonal antibodies that distinguish three antigenic sites on human cytomegalovirus glycoprotein H have conformationally distinct binding sites.

Authors:  J A Simpson; J C Chow; J Baker; N Avdalovic; S Yuan; D Au; M S Co; M Vasquez; W J Britt; K L Coelingh
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

2.  Comparative sequence analysis of human cytomegalovirus strains.

Authors:  R Lehner; T Stamminger; M Mach
Journal:  J Clin Microbiol       Date:  1991-11       Impact factor: 5.948

3.  Strain-specific neutralization of human cytomegalovirus isolates by human sera.

Authors:  M Klein; K Schoppel; N Amvrossiadis; M Mach
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103

4.  The dominant linear neutralizing antibody-binding site of glycoprotein gp86 of human cytomegalovirus is strain specific.

Authors:  M Urban; W Britt; M Mach
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

5.  Human cytomegalovirus neutralizing antibody-resistant phenotype is associated with reduced expression of glycoprotein H.

Authors:  L Li; K L Coelingh; W J Britt
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

Review 6.  A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection.

Authors:  Cody S Nelson; Betsy C Herold; Sallie R Permar
Journal:  NPJ Vaccines       Date:  2018-09-20       Impact factor: 9.399
  6 in total

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