| Literature DB >> 25573804 |
Philip L S M Gordts1, Jeffrey D Esko2.
Abstract
Macrophages are important mediators of diseases associated with metabolic inflammation such as obesity and atherosclerosis. In this Stimulus we discuss recent findings showing that heparan sulfate proteoglycans on macrophages serve as an important inflammatory rheostat. This observation has significant implications as the degree of macrophage proteoglycan sulfation can determine and possibly predict disease outcomes of metabolic inflammatory disorders.Entities:
Keywords: Atherosclerosis; Heparan sulfate proteoglycans; Macrophages; Obesity; Type I Interferon
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Year: 2015 PMID: 25573804 DOI: 10.1016/j.cyto.2014.12.013
Source DB: PubMed Journal: Cytokine ISSN: 1043-4666 Impact factor: 3.861