Literature DB >> 25572883

Mx GTPases: dynamin-like antiviral machines of innate immunity.

Otto Haller1, Peter Staeheli2, Martin Schwemmle3, Georg Kochs3.   

Abstract

The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the viral replication cycle. We focus on new structural and functional insights and discuss recent data revealing that human MxA (MX1) provides a safeguard against introduction of avian influenza A viruses (FLUAV) into the human population. The related human MxB (MX2) serves as restriction factor for HIV-1 and other primate lentiviruses.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV-1; dynamin-like GTPase; influenza; innate immunity; interferon; primate evolution

Mesh：

Substances：

Year:  2015        PMID： 25572883     DOI： 10.1016/j.tim.2014.12.003

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  156 in total

1.  Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.

Authors:  Romain Bouziat; Scott B Biering; Elaine Kouame; Kishan A Sangani; Soowon Kang; Jordan D Ernest; Mukund Varma; Judy J Brown; Kelly Urbanek; Terence S Dermody; Aylwin Ng; Reinhard Hinterleitner; Seungmin Hwang; Bana Jabri
Journal:  Cell Host Microbe       Date:  2018-11-01       Impact factor: 21.023

Review 2.  Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells.

Authors:  Ryan G Gaudet; Clinton J Bradfield; John D MacMicking
Journal:  Microbiol Spectr       Date:  2016-12

3.  Human MxB Protein Is a Pan-herpesvirus Restriction Factor.

Authors:  Mirjam Schilling; Lorenzo Bulli; Sebastian Weigang; Laura Graf; Sebastian Naumann; Corinna Patzina; Valentina Wagner; Liane Bauersfeld; Caroline Goujon; Hartmut Hengel; Anne Halenius; Zsolt Ruzsics; Torsten Schaller; Georg Kochs
Journal:  J Virol       Date:  2018-08-16       Impact factor: 5.103

4.  Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease.

Authors:  Padmini S Pillai; Ryan D Molony; Kimberly Martinod; Huiping Dong; Iris K Pang; Michal C Tal; Angel G Solis; Piotr Bielecki; Subhasis Mohanty; Mark Trentalange; Robert J Homer; Richard A Flavell; Denisa D Wagner; Ruth R Montgomery; Albert C Shaw; Peter Staeheli; Akiko Iwasaki
Journal:  Science       Date:  2016-04-22       Impact factor: 47.728

5.  Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization Signal.

Authors:  Bianca Schulte; Cindy Buffone; Silvana Opp; Francesca Di Nunzio; Daniel Augusto De Souza Aranha Vieira; Alberto Brandariz-Nuñez; Felipe Diaz-Griffero
Journal:  J Virol       Date:  2015-06-10       Impact factor: 5.103

Review 6.  Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1.

Authors:  Peter Staeheli; Otto Haller
Journal:  J Virol       Date:  2018-11-27       Impact factor: 5.103

7.  Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

Authors:  Melissa Kane; Stephanie V Rebensburg; Matthew A Takata; Trinity M Zang; Masahiro Yamashita; Mamuka Kvaratskhelia; Paul D Bieniasz
Journal:  Elife       Date:  2018-08-07       Impact factor: 8.140

8.  Eurasian Avian-Like Swine Influenza A Viruses Escape Human MxA Restriction through Distinct Mutations in Their Nucleoprotein

Authors:  Dominik Dornfeld; Philipp P Petric; Ebrahim Hassan; Roland Zell; Martin Schwemmle
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

9.  Genotype frequency contributions of Mx1 gene in eight chicken breeds under different selection pressures.

Authors:  Jingjing Li; Chaowu Yang; Jinshan Ran; Xiaosong Jiang; Huarui Du; Zhiqiang Li; Yiping Liu; Long Zhang
Journal:  3 Biotech       Date:  2018-11-14       Impact factor: 2.406

10.  Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action.

Authors:  Jinling Chen; Yuejin Liang; Panpan Yi; Lanman Xu; Hal K Hawkins; Shannan L Rossi; Lynn Soong; Jiyang Cai; Ramkumar Menon; Jiaren Sun
Journal:  Cell Rep       Date:  2017-11-07       Impact factor: 9.423
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