Seung-Geun Lee1, In-Joo Kim2, Keun-Young Kim3, Hee-Young Kim4, Kyoung-June Park4, Seong-Jang Kim4, Eun-Kyoung Park1, Yun-Kyung Jeon1, Byeong-Yun Yang1, Geun-Tae Kim5. 1. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea. 2. Department of Internal Medicine, and Department of Nuclear Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea. 3. Department of Nuclear Medicine, Kosin University College of Medicine, Busan, South Korea. 4. Department of Nuclear Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea. 5. Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea.
Abstract
OBJECTIVES: 18F-fluoride uptake represents active osteoblastic bone synthesis. We assessed bone synthetic activity in inflammatory lesions and syndesmophytes in patients with ankylosing spondylitis (AS) using 18F-fluoride positron emission tomography-magnetic resonance imaging (PET-MRI, Philips Healthcare, Cleveland, OH, USA) and x-ray. METHODS: All images of 12 AS patients were recorded with the presence or absence of increased 18F-fluoride uptake lesions on PET, acute (type A) or advanced (type B) corner inflammatory lesions (CILs) on MRI, syndesmophytes on x-ray at the anterior vertebral corners. An increased 18F-fluoride uptake lesion was defined as an uptake which is greater than the uptake in the adjacent normal vertebral body. The association of a CIL or syndesmophyte with an increased 18F-fluoride uptake lesion was investigated by generalised linear latent mixed models analysis to adjust within-patient dependence for total numbers of vertebral corners. RESULTS: There were 67 type A CILs (12.1%), 37 type B CILs (6.7%) and 58 increased 18F-fluoride uptake lesion (10.4%) out of 552 vertebral corners and there were 57 syndesmophytes (19.8%) out of 288 vertebral corners. A type A CIL (OR=3.2, 95% CI=1.6-6.5, p=0.001), type B CIL (OR=59.9, 95% CI=23.5-151.5, p<0.001) and syndesmpophyte (OR=21.8, 95% CI=5.5-85.2, p<0.001) were significantly associated with an increased 18F-fluoride uptake lesion. CONCLUSIONS: Our data suggest that an inflammatory lesion as well as a syndesmophyte is associated with active bone synthesis assessed by 18F-fluoride uptake in the spine of AS patients. 18F-fluoride PET-MRI may have the potential for investigating the pathogenesis of structural damage in AS.
OBJECTIVES:18F-fluoride uptake represents active osteoblastic bone synthesis. We assessed bone synthetic activity in inflammatory lesions and syndesmophytes in patients with ankylosing spondylitis (AS) using 18F-fluoride positron emission tomography-magnetic resonance imaging (PET-MRI, Philips Healthcare, Cleveland, OH, USA) and x-ray. METHODS: All images of 12 AS patients were recorded with the presence or absence of increased 18F-fluoride uptake lesions on PET, acute (type A) or advanced (type B) corner inflammatory lesions (CILs) on MRI, syndesmophytes on x-ray at the anterior vertebral corners. An increased 18F-fluoride uptake lesion was defined as an uptake which is greater than the uptake in the adjacent normal vertebral body. The association of a CIL or syndesmophyte with an increased 18F-fluoride uptake lesion was investigated by generalised linear latent mixed models analysis to adjust within-patient dependence for total numbers of vertebral corners. RESULTS: There were 67 type A CILs (12.1%), 37 type B CILs (6.7%) and 58 increased 18F-fluoride uptake lesion (10.4%) out of 552 vertebral corners and there were 57 syndesmophytes (19.8%) out of 288 vertebral corners. A type A CIL (OR=3.2, 95% CI=1.6-6.5, p=0.001), type B CIL (OR=59.9, 95% CI=23.5-151.5, p<0.001) and syndesmpophyte (OR=21.8, 95% CI=5.5-85.2, p<0.001) were significantly associated with an increased 18F-fluoride uptake lesion. CONCLUSIONS: Our data suggest that an inflammatory lesion as well as a syndesmophyte is associated with active bone synthesis assessed by 18F-fluoride uptake in the spine of AS patients. 18F-fluoride PET-MRI may have the potential for investigating the pathogenesis of structural damage in AS.
Authors: William Raynor; Sina Houshmand; Saeid Gholami; Sahra Emamzadehfard; Chamith S Rajapakse; Björn Alexander Blomberg; Thomas J Werner; Poul F Høilund-Carlsen; Joshua F Baker; Abass Alavi Journal: Curr Osteoporos Rep Date: 2016-08 Impact factor: 5.096
Authors: Stefan T G Bruijnen; Nicki J F Verweij; Leonie M van Duivenvoorde; Nathalie Bravenboer; Dominique L P Baeten; Christiaan J van Denderen; Irene E van der Horst-Bruinsma; Alexandre E Voskuyl; Martijn Custers; Peter M van de Ven; Joost C J Bot; Bouke J H Boden; Adriaan A Lammertsma; Otto S H Hoekstra; Pieter G H M Raijmakers; Conny J van der Laken Journal: Rheumatology (Oxford) Date: 2018-04-01 Impact factor: 7.580