BACKGROUND: Acne reflects hormone imbalance and is a key component of several systemic diseases. We hypothesized that diagnosis of acne as a teenager might predict subsequent risk of hormone-related cancers. METHODS: We followed 99,128 female nurses in the Nurses' Health Study II cohort for 20 years (1989-2009) and used Cox proportional hazards models to estimate the hazard ratios (HRs) of 8 specific cancers (breast, thyroid, colorectal, ovarian, cervical, and endometrial cancers, melanoma, and non-Hodgkin lymphoma) for women with a history of severe teenage acne. RESULTS: After thoroughly adjusting for the previously known risk factors for each cancer, we found that among women with a history of severe teenage acne, the relative risk increased, with a multivariable-adjusted HR of 1.44 (95% confidence interval [CI], 1.03-2.01) for melanoma. We replicated this association in an independent melanoma case-control study of 930 cases and 1026 controls (multivariable-adjusted odds ratio, 1.27; 95% CI, 1.03-1.56). We also found that in both studies the individuals with teenage acne were more likely to have moles (52.7% vs 50.1%, P < .001 in the cohort study; and 55.2% vs 45.1%, P = .004 in the case-control study). CONCLUSIONS: Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships.
BACKGROUND:Acne reflects hormone imbalance and is a key component of several systemic diseases. We hypothesized that diagnosis of acne as a teenager might predict subsequent risk of hormone-related cancers. METHODS: We followed 99,128 female nurses in the Nurses' Health Study II cohort for 20 years (1989-2009) and used Cox proportional hazards models to estimate the hazard ratios (HRs) of 8 specific cancers (breast, thyroid, colorectal, ovarian, cervical, and endometrial cancers, melanoma, and non-Hodgkin lymphoma) for women with a history of severe teenage acne. RESULTS: After thoroughly adjusting for the previously known risk factors for each cancer, we found that among women with a history of severe teenage acne, the relative risk increased, with a multivariable-adjusted HR of 1.44 (95% confidence interval [CI], 1.03-2.01) for melanoma. We replicated this association in an independent melanoma case-control study of 930 cases and 1026 controls (multivariable-adjusted odds ratio, 1.27; 95% CI, 1.03-1.56). We also found that in both studies the individuals with teenage acne were more likely to have moles (52.7% vs 50.1%, P < .001 in the cohort study; and 55.2% vs 45.1%, P = .004 in the case-control study). CONCLUSIONS: Our findings suggest that a history of teenage acne might be a novel risk factor for melanoma independent from the known factors, which supports a need for continued investigation of these relationships.
Authors: Christopher I Amos; Li-E Wang; Jeffrey E Lee; Jeffrey E Gershenwald; Wei V Chen; Shenying Fang; Roman Kosoy; Mingfeng Zhang; Abrar A Qureshi; Selina Vattathil; Christopher W Schacherer; Julie M Gardner; Yuling Wang; D Tim Bishop; Jennifer H Barrett; Stuart MacGregor; Nicholas K Hayward; Nicholas G Martin; David L Duffy; Graham J Mann; Anne Cust; John Hopper; Kevin M Brown; Elizabeth A Grimm; Yaji Xu; Younghun Han; Kaiyan Jing; Caitlin McHugh; Cathy C Laurie; Kim F Doheny; Elizabeth W Pugh; Michael F Seldin; Jiali Han; Qingyi Wei Journal: Hum Mol Genet Date: 2011-09-17 Impact factor: 6.150
Authors: G A Colditz; P Martin; M J Stampfer; W C Willett; L Sampson; B Rosner; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1986-05 Impact factor: 4.897
Authors: Marjolein N Kooijman; Claudia J Kruithof; Cornelia M van Duijn; Liesbeth Duijts; Oscar H Franco; Marinus H van IJzendoorn; Johan C de Jongste; Caroline C W Klaver; Aad van der Lugt; Johan P Mackenbach; Henriëtte A Moll; Robin P Peeters; Hein Raat; Edmond H H M Rings; Fernando Rivadeneira; Marc P van der Schroeff; Eric A P Steegers; Henning Tiemeier; André G Uitterlinden; Frank C Verhulst; Eppo Wolvius; Janine F Felix; Vincent W V Jaddoe Journal: Eur J Epidemiol Date: 2017-01-09 Impact factor: 8.082
Authors: Wen-Qing Li; Aaron M Drucker; Eunyoung Cho; Francine Laden; Trang VoPham; Suyun Li; Martin A Weinstock; Abrar A Qureshi Journal: Br J Cancer Date: 2017-10-26 Impact factor: 7.640