Literature DB >> 2557245

Protein kinase C phosphorylates DNA topoisomerase I.

D S Samuels1, Y Shimizu, N Shimizu.   

Abstract

The induction of mammalian cell proliferation requires the expression of a specific set of genes. Tumor promoters stimulate cell growth by activating the Ca2+ and phospholipid-dependent protein kinase, protein kinase C (PKC). DNA topoisomerase I, a nuclear enzyme involved in transcription, was phosphorylated by activated PKC in vitro. Phosphorylation by PKC stimulated the DNA relaxation activity of topoisomerase I two- to three-fold. Therefore, DNA topoisomerase I is a substrate for PKC-mediated activation by phosphorylation and may serve as a nuclear target of mitogenic signals generated by tumor promoters in vivo.

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Year:  1989        PMID： 2557245     DOI： 10.1016/0014-5793(89)81493-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

1.  eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI.

Authors:  Manuela Piazzi; Alberto Bavelloni; Irene Faenza; William Blalock; Andrea Urbani; Simona D'Aguanno; Roberta Fiume; Giulia Ramazzotti; Nadir Mario Maraldi; Lucio Cocco
Journal:  Mol Cell Proteomics       Date:  2010-10-05       Impact factor: 5.911

2.  Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines.

Authors:  Keya Bandyopadhyay; Ruth A Gjerset
Journal:  Biochemistry       Date:  2011-01-12       Impact factor: 3.162

Review 3.  Nuclear lipid metabolism in NEST: Nuclear Envelope Signal Transduction.

Authors:  D M Raben; M B Jarpe; K L Leach
Journal:  J Membr Biol       Date:  1994-10       Impact factor: 1.843

Review 4.  DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?

Authors:  A K Larsen; C Gobert
Journal:  Pathol Oncol Res       Date:  1999       Impact factor: 3.201

5.  Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

Authors:  J C Hsieh; P W Jurutka; M A Galligan; C M Terpening; C A Haussler; D S Samuels; Y Shimizu; N Shimizu; M R Haussler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

6.  Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.

Authors:  W Zhang; H Yamada; N Sakai; Y Nozawa
Journal:  J Neurooncol       Date:  1993-01       Impact factor: 4.130

7.  Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I.

Authors:  Jennifer S Hackbarth; Marina Galvez-Peralta; Nga T Dai; David A Loegering; Kevin L Peterson; Xue W Meng; Larry M Karnitz; Scott H Kaufmann
Journal:  J Biol Chem       Date:  2008-04-11       Impact factor: 5.157

8.  Phosphorylation of human topoisomerase I by protein kinase C in vitro and in phorbol 12-myristate 13-acetate-activated HL-60 promyelocytic leukaemia cells.

Authors:  E Cardellini; E Durban
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

9.  Protein kinase C modulation in apoptotic rat thymocytes: an ultrastructural analysis.

Authors:  O Trubiani; P Borgatti; R Di Primio
Journal:  Histochemistry       Date:  1994-10

10.  Inhibition of DNA topoisomerase I activity by heparan sulfate and modulation by basic fibroblast growth factor.

Authors:  I Kovalszky; J Dudás; J Oláh-Nagy; G Pogány; J Töváry; J Timár; L Kopper; A Jeney; R V Iozzo
Journal:  Mol Cell Biochem       Date:  1998-06       Impact factor: 3.396
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