Cynthia Wei-Sheng Lee1, Chun-Hui Liao2, Cheng-Li Lin3, Ji-An Liang4, Fung-Chang Sung5, Chia-Hung Kao6. 1. Center for Drug Abuse and Addiction, China Medical University Hospital, Taichung, Taiwan. 2. Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan. 3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan. 4. Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. 5. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. 6. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan. Electronic address: d10040@mail.cmuh.org.tw.
Abstract
OBJECTIVE: To investigate the relationship between depression and risk of subsequent osteoporosis development. PARTICIPANTS AND METHODS: A population-based retrospective cohort analysis was conducted using the Longitudinal Health Insurance Database 2000 of Taiwan. We included 32,978 patients in the depression cohort and 131,912 patients in the no-depression cohort between January 1, 1998, and December 31, 2008, and calculated the incidence rates of newly diagnosed osteoporosis. We used Cox proportional hazards models to assess the effects of depression. The Kaplan-Meier method was applied to estimate the cumulative osteoporosis incidence curves. RESULTS: Patients with depression were 1.30 times more likely to experience osteoporosis than those without depression. The risk was higher for patients with severe depression and mild depression than for those without depression. A greater hazard ratio magnitude was observed in patients aged 35 to 49 years. We also observed a significant decrease in osteoporosis risk in patients with depression treated with antidepressant agents. CONCLUSION: The incidence of osteoporosis in Taiwan is associated with an a priori depression history. The risk was identified in both men and women, particularly in patients aged 35 to 49 years, and was inversely correlated with antidepressant drug treatment.
OBJECTIVE: To investigate the relationship between depression and risk of subsequent osteoporosis development. PARTICIPANTS AND METHODS: A population-based retrospective cohort analysis was conducted using the Longitudinal Health Insurance Database 2000 of Taiwan. We included 32,978 patients in the depression cohort and 131,912 patients in the no-depression cohort between January 1, 1998, and December 31, 2008, and calculated the incidence rates of newly diagnosed osteoporosis. We used Cox proportional hazards models to assess the effects of depression. The Kaplan-Meier method was applied to estimate the cumulative osteoporosis incidence curves. RESULTS:Patients with depression were 1.30 times more likely to experience osteoporosis than those without depression. The risk was higher for patients with severe depression and mild depression than for those without depression. A greater hazard ratio magnitude was observed in patients aged 35 to 49 years. We also observed a significant decrease in osteoporosis risk in patients with depression treated with antidepressant agents. CONCLUSION: The incidence of osteoporosis in Taiwan is associated with an a priori depression history. The risk was identified in both men and women, particularly in patients aged 35 to 49 years, and was inversely correlated with antidepressant drug treatment.
Authors: Chen Hong-Jhe; Kuo Chin-Yuan; Tu Ming-Shium; Wang Fu-Wei; Chen Ru-Yih; Hsueh Kuang-Chieh; Pan Hsiang-Ju; Chou Ming-Yueh; Chen Pan-Ming; Pan Chih-Chuan Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889
Authors: M I Lapid; S Kung; M A Frye; J M Biernacka; J R Geske; M T Drake; M D Jankowski; B L Clarke Journal: Transl Psychiatry Date: 2017-08-22 Impact factor: 6.222