Literature DB >> 25572105

Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products.

Michail Tsakos1, Eva S Schaffert, Lise L Clement, Nikolaj L Villadsen, Thomas B Poulsen.   

Abstract

In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester couplings and on this mechanistic background we then present and discuss a collection of successful examples from the literature.

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Year:  2015        PMID： 25572105     DOI： 10.1039/c4np00106k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  20 in total

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