Yi Li1, Wai Tsui2, Henry Rusinek2, Tracy Butler3, Lisa Mosconi2, Elizabeth Pirraglia2, David Mozley4, Shankar Vallabhajosula4, Ryuichi Harada5, Shozo Furumoto6, Katsutoshi Furukawa5, Hiroyuki Arai5, Yukitsuka Kudo5, Nobuyuki Okamura7, Mony J de Leon8. 1. Center for Brain Health, New York University, New York, New York Shandong University, Shandong, China. 2. Center for Brain Health, New York University, New York, New York. 3. Center for Brain Health, New York University, New York, New York Cornell University, Ithaca, New York. 4. Cornell University, Ithaca, New York. 5. Institute of Development, Aging, and Cancer, Sendai, Japan. 6. Cyclotron and Radioisotope Center, Sendai, Japan. 7. Institute of Development, Aging, and Cancer, Sendai, Japan Tohoku University School of Medicine, Sendai, Japan; and. 8. Center for Brain Health, New York University, New York, New York The Steven and Alexandra Cohen Veterans Center at NYU, New York, New York mony.deleon@nyumc.org.
Abstract
UNLABELLED: Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon. METHODS: Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter-white matter boundary. We studied 5 AD and 5 healthy subjects with both (18)F-THK5117 (tau) and (11)C-Pittsburgh compound B (Aβ) PET. RESULTS: On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects and for all regions, both before and after regionally adjusting for the nonspecific white matter binding of both tracers. The differential laminar pattern was validated through postmortem examination. CONCLUSION: Within cortical lamina, distance measures may be of value in testing PET tracers for their anatomic selectivity.
UNLABELLED: Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions. Neurofibrillary-tangle tau pathology tends to be closer to the gray matter-white matter boundary, whereas Aβ is dispersed throughout the width of the cortical ribbon. METHODS: Using PET radiotracers for tau and Aβ lesions, we developed an image analysis tool to measure the distance of tracer-positive voxels from the gray matter-white matter boundary. We studied 5 AD and 5 healthy subjects with both (18)F-THK5117 (tau) and (11)C-Pittsburgh compound B (Aβ) PET. RESULTS: On average, tau-positive voxels were closer to the white matter than were Aβ-positive voxels. This effect was found for all AD subjects and for all regions, both before and after regionally adjusting for the nonspecific white matter binding of both tracers. The differential laminar pattern was validated through postmortem examination. CONCLUSION: Within cortical lamina, distance measures may be of value in testing PET tracers for their anatomic selectivity.
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