Literature DB >> 25572043

The social gradient of fractures at any skeletal site in men and women: data from the Geelong Osteoporosis Study Fracture Grid.

S L Brennan1, K L Holloway, L J Williams, M A Kotowicz, G Bucki-Smith, D J Moloney, A G Dobbins, E N Timney, J A Pasco.   

Abstract

UNLABELLED: Age-specific and age-standardized associations between socioeconomic status (SES) and fractures in adults showed a social gradient of fracture, irrespective of fracture site. Compared to the highest SES, males in the lowest SES group had a sixfold increased odds for any fracture, whilst females had a twofold increased odds.
INTRODUCTION: The effective identification of predisposing risk factors for fracture requires understanding any association with SES. These investigations should consider both sexes, span the adult age range and include any fractures. We investigated age- and sex-specific and age-standardized associations between SES and fractures at any skeletal site in Australians aged ≥ 50 years.
METHODS: Incident fractures that occurred 2006-2007 for adults aged ≥ 50 years were identified from radiological reports extracted for the Barwon Statistical Division, in south-eastern Australia. SES was determined by cross-referencing residential addresses with Australian Bureau of Statistics census data and then categorized in quintiles. We compared frequencies of observed vs. expected fractures for SES quintiles using χ (2) comparison, calculated age-specific fracture incidence across SES and compared age-standardized fracture rates in SES quintile 1 to quintile 5.
RESULTS: We identified 3943 incident fractures (69.4 % female); 47.4 % had occurred at major osteoporotic fracture (MOF) sites (hip, humerus, spine and forearm/wrist). Differences existed in observed vs. expected fractures across SES quintiles (p ≤ 0.001, sexes combined); all fractures showed an inverse association with SES (p ≤ 0.001, sexes combined). Compared to the highest SES quintile, individuals from the lowest SES quintile had between two to six times greater standardized fracture rates.
CONCLUSIONS: Disadvantaged men and women have an increased fracture incidence compared to their less disadvantaged counterparts. The large differences in fracture rates between SES groups warrant further research into designing appropriate, targeted interventions for those demographics at most risk.

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Year:  2015        PMID: 25572043     DOI: 10.1007/s00198-014-3004-y

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  26 in total

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Review 2.  The association between socioeconomic status and osteoporotic fracture in population-based adults: a systematic review.

Authors:  S L Brennan; J A Pasco; D M Urquhart; B Oldenburg; F Hanna; A E Wluka
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3.  Socioeconomic status in relation to incident fracture risk in the Study of Women's Health Across the Nation.

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Authors:  J A Pasco; M J Henry; T M Gaudry; G C Nicholson; M A Kotowicz
Journal:  Aust N Z J Med       Date:  1999-04

7.  The human cost of fracture.

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Review 5.  Fractures in indigenous compared to non-indigenous populations: A systematic review of rates and aetiology.

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