Yukihiro Kitai1, Satori Hirai2, Kayo Ohmura2, Kaeko Ogura2, Hiroshi Arai2. 1. Department of Pediatric Neurology, Morinomiya Hospital, Osaka 536-0025, Japan. Electronic address: kitai@omichikai.or.jp. 2. Department of Pediatric Neurology, Morinomiya Hospital, Osaka 536-0025, Japan.
Abstract
OBJECTIVES: To elucidate the prevalence of cerebellar injury and its relationship to functional outcomes in preterm children with cerebral palsy (CP) after intraventricular hemorrhage (IVH). PARTICIPANTS: We selected 69 children (40 males and 29 females, aged between 6 and 13 years) out of 2049 with cerebral palsy who visited Morinomiya Hospital, the regional center hospital for CP in West Japan. The inclusion criteria were (1) gestational age under 36 weeks at birth, (2) clear history of postnatal intraventricular hemorrhage, and (3) age at investigation over 6 years old. Those without sufficient imaging study or functional evaluation were excluded. METHODS: The participants were divided into four groups according to the presence of post-hemorrhagic hydrocephalus (PH) and cerebellar injury (CI): PH+/CI+, PH+/CI-, PH-/CI+, and PH-/CI-. Type of CP, ability to walk, verbal function, the incidence of severe visual impairment, and the complication of epilepsy were investigated and compared among the groups. RESULTS: The gestational ages of the participants were between 22 and 34 weeks, and their birth weight was between 412 and 1788 g. PH and CI were found in 39 (57%) and 40 (58%) children, respectively. Both the PH+/CI+ group (n=31) and the PH-/CI+ group (n=9) showed significantly lower walking and verbal abilities and a higher incidence of epilepsy than the PH-/CI- group (n=21), while the PH+/CI- group showed no significant difference from the PH-/CI- group. Severe visual impairment was found only in the PH+/CI+ group and the PH-/CI+ group. CONCLUSIONS: The prevalence of CI in preterm children with CP after IVH (58%) was almost the same as that of PH. CI is one of the most significant complications in preterm infants, affecting motor and verbal functions and being associated with epilepsy more than PH.
OBJECTIVES: To elucidate the prevalence of cerebellar injury and its relationship to functional outcomes in preterm children with cerebral palsy (CP) after intraventricular hemorrhage (IVH). PARTICIPANTS: We selected 69 children (40 males and 29 females, aged between 6 and 13 years) out of 2049 with cerebral palsy who visited Morinomiya Hospital, the regional center hospital for CP in West Japan. The inclusion criteria were (1) gestational age under 36 weeks at birth, (2) clear history of postnatal intraventricular hemorrhage, and (3) age at investigation over 6 years old. Those without sufficient imaging study or functional evaluation were excluded. METHODS: The participants were divided into four groups according to the presence of post-hemorrhagic hydrocephalus (PH) and cerebellar injury (CI): PH+/CI+, PH+/CI-, PH-/CI+, and PH-/CI-. Type of CP, ability to walk, verbal function, the incidence of severe visual impairment, and the complication of epilepsy were investigated and compared among the groups. RESULTS: The gestational ages of the participants were between 22 and 34 weeks, and their birth weight was between 412 and 1788 g. PH and CI were found in 39 (57%) and 40 (58%) children, respectively. Both the PH+/CI+ group (n=31) and the PH-/CI+ group (n=9) showed significantly lower walking and verbal abilities and a higher incidence of epilepsy than the PH-/CI- group (n=21), while the PH+/CI- group showed no significant difference from the PH-/CI- group. Severe visual impairment was found only in the PH+/CI+ group and the PH-/CI+ group. CONCLUSIONS: The prevalence of CI in preterm children with CP after IVH (58%) was almost the same as that of PH. CI is one of the most significant complications in preterm infants, affecting motor and verbal functions and being associated with epilepsy more than PH.
Authors: Karl C K Kuban; Hernan Jara; T Michael O'Shea; Timothy Heeren; Robert M Joseph; Raina N Fichorova; Khalid Alshamrani; Adam Aakil; Forrest Beaulieu; Mitchell Horn; Laurie M Douglass; Jean A Frazier; Deborah Hirtz; Julie Vanier Rollins; David Cochran; Nigel Paneth Journal: J Pediatr Date: 2019-05-07 Impact factor: 4.406
Authors: Alex Adusei Agyemang; Kristbjörg Sveinsdóttir; Suvi Vallius; Snjolaug Sveinsdóttir; Matteo Bruschettini; Olga Romantsik; Ann Hellström; Lois E H Smith; Lennart Ohlsson; Bo Holmqvist; Magnus Gram; David Ley Journal: Transl Stroke Res Date: 2017-06-10 Impact factor: 6.829