Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation: a computational modeling study.

In this study, ON and OFF retinal ganglion cell (RGC) models based on accurate biophysics and realistic representations of cell morphologies were used to understand how these cells selectively respond to high-frequency electrical stimulation (HFS). With optimized model parameters and the incorporation of detailed cell morphologies, these two models were able to closely replicate experimental ON and OFF RGC responses to epiretinal electrical stimulation. This modeling approach can be used to design electrical stimulus profiles capable of cell-specific activation, and is broadly applicable for the development of sophisticated stimulation strategies for visual prostheses.