Literature DB >> 2557116

Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.

C H Heldin, B Westermark.   

Abstract

Platelet-derived growth factor (PDGF) is a mitogen for connective tissue cells and occurs as disulphide-bonded homodimers or heterodimers of related polypeptide chains. Recent data indicate that the isoforms have different functional activities due to the fact that they bind with different affinities to two distinct receptor types. The frequent expression of PDGF and PDGF receptors in normal as well as transformed cells, suggests roles for PDGF in autocrine and paracrine stimulation of cell growth in vivo.

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Year:  1989        PMID： 2557116     DOI： 10.1093/oxfordjournals.bmb.a072334

Source DB:  PubMed          Journal:  Br Med Bull        ISSN： 0007-1420            Impact factor:   4.291


  12 in total

1.  MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway.

Authors:  Yanzhi Yang; Samantha Dodbele; Thomas Park; Rainer Glass; Krishna Bhat; Erik P Sulman; Ying Zhang; Roger Abounader
Journal:  J Neurooncol       Date:  2019-09-03       Impact factor: 4.130

2.  Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. I. Evidence for reversible binding and inactivation of the platelet-derived growth factor by heparin.

Authors:  G Fager; G Camejo; G Bondjers
Journal:  In Vitro Cell Dev Biol       Date:  1992-03

3.  Platelet-derived growth factor involvement in myocardial remodeling following infarction.

Authors:  Wenyuan Zhao; Tieqiang Zhao; Valerie Huang; Yuanjian Chen; Robert A Ahokas; Yao Sun
Journal:  J Mol Cell Cardiol       Date:  2011-07-13       Impact factor: 5.000

4.  Gangliosides inhibit PDGF-induced signal transduction events in U-1242 MG human glioma cells.

Authors:  H E Saqr; J D Walters; Z Guan; B T Stokes; A J Yates
Journal:  Neurochem Res       Date:  1995-11       Impact factor: 3.996

5.  Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells.

Authors:  M Yang; K Li; A C Lam; P M Yuen; T F Fok; C N Chesterman; B H Chong
Journal:  Int J Hematol       Date:  2001-04       Impact factor: 2.490

Review 6.  Platelet-Rich Plasma as an Alternative to Xenogeneic Sera in Cell-Based Therapies: A Need for Standardization.

Authors:  Eduardo Anitua; Mar Zalduendo; Maria Troya; Mohammad H Alkhraisat; Leticia Alejandra Blanco-Antona
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

7.  Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts.

Authors:  Tieqiang Zhao; Wenyuan Zhao; Yuanjian Chen; Victoria S Li; Weixin Meng; Yao Sun
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-04-12       Impact factor: 4.733

8.  Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.

Authors:  M Centrella; T L McCarthy; W F Kusmik; E Canalis
Journal:  J Clin Invest       Date:  1992-04       Impact factor: 14.808

9.  Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.

Authors:  J M Clements; L J Bawden; R E Bloxidge; G Catlin; A L Cook; S Craig; A H Drummond; R M Edwards; A Fallon; D R Green
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598

10.  Expression of insulin-like growth factors (IGFs), their receptors and IGF binding protein-3 in normal, benign and malignant smooth muscle tissues.

Authors:  L T Van der Ven; P J Roholl; T Gloudemans; S C Van Buul-Offers; M J Welters; B A Bladergroen; J A Faber; J S Sussenbach; W Den Otter
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640
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