Literature DB >> 25570601

Nanograting structure promotes lamellipodia-based cell collective migration and wound healing.

Zaozao Chen, Leigh Atchison, HaYeun Ji, Kam W Leong.   

Abstract

Wound healing is a dynamic and complex process of replacing missing or dead cell structures and tissue layers. The aim of this research is to discover biocompatible materials and drugs that can promote cell migration in the wound area and thus enhance desirable wound healing effects. In this paper, we report that PDMS nanogratings could accelerate the migration of epithelial cells along the grating axis, and the addition of Imatinib could further increase the epithelial cell wound healing speed to 1.6 times the speed of control cells. We also demonstrate that this migration is mediated by lamellipodia protrusion, and is Rac1-GTPase activity dependent. Lastly, we discuss the potential application and prospect of different nanostructured biomaterials for wound healing studies.

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Year:  2014        PMID： 25570601      PMCID： PMC4697883          DOI： 10.1109/EMBC.2014.6944233

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN： 1557-170X


  14 in total

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Authors:  Kevin Kit Parker; Amy Lepre Brock; Cliff Brangwynne; Robert J Mannix; Ning Wang; Emanuele Ostuni; Nicholas A Geisse; Josephine C Adams; George M Whitesides; Donald E Ingber
Journal:  FASEB J       Date:  2002-08       Impact factor: 5.191

2.  Effect of orientation and density of nanotopography in dermal wound healing.

Authors:  Hong Nam Kim; Yoonmi Hong; Min Sung Kim; Sun Min Kim; Kahp-Yang Suh
Journal:  Biomaterials       Date:  2012-09-06       Impact factor: 12.479

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Authors:  Shen Liu; Mingjie Qin; Changmin Hu; Fei Wu; Wenguo Cui; Tuo Jin; Cunyi Fan
Journal:  Biomaterials       Date:  2013-03-26       Impact factor: 12.479

4.  Time-lapse videomicroscopic study of in vitro wound closure in rabbit corneal cells.

Authors:  K Y Chan; D L Patton; Y T Cosgrove
Journal:  Invest Ophthalmol Vis Sci       Date:  1989-12       Impact factor: 4.799

5.  Nanotopography as modulator of human mesenchymal stem cell function.

Authors:  Karina Kulangara; Yong Yang; Jennifer Yang; Kam W Leong
Journal:  Biomaterials       Date:  2012-04-18       Impact factor: 12.479

6.  Intracellular fluid flow in rapidly moving cells.

Authors:  Kinneret Keren; Patricia T Yam; Anika Kinkhabwala; Alex Mogilner; Julie A Theriot
Journal:  Nat Cell Biol       Date:  2009-09-20       Impact factor: 28.824

7.  Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing.

Authors:  Srinivasulu Chigurupati; Mohamed R Mughal; Eitan Okun; Soumen Das; Amit Kumar; Michael McCaffery; Sudipta Seal; Mark P Mattson
Journal:  Biomaterials       Date:  2012-12-23       Impact factor: 12.479

8.  An adhesion-dependent switch between mechanisms that determine motile cell shape.

Authors:  Erin L Barnhart; Kun-Chun Lee; Kinneret Keren; Alex Mogilner; Julie A Theriot
Journal:  PLoS Biol       Date:  2011-05-03       Impact factor: 8.029

9.  Rho GTPases control polarity, protrusion, and adhesion during cell movement.

Authors:  C D Nobes; A Hall
Journal:  J Cell Biol       Date:  1999-03-22       Impact factor: 10.539

10.  Locomotion and cell-substratum contacts of Xenopus epidermal cells in vitro and in situ.

Authors:  G P Radice
Journal:  J Cell Sci       Date:  1980-08       Impact factor: 5.285
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  2 in total

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Authors:  Erdem D Tabdanov; Nelson J Rodríguez-Merced; Alexander X Cartagena-Rivera; Vikram V Puram; Mackenzie K Callaway; Ethan A Ensminger; Emily J Pomeroy; Kenta Yamamoto; Walker S Lahr; Beau R Webber; Branden S Moriarity; Alexander S Zhovmer; Paolo P Provenzano
Journal:  Nat Commun       Date:  2021-05-14       Impact factor: 14.919

2.  Rapid Prototyping of Polymeric Nanopillars by 3D Direct Laser Writing for Controlling Cell Behavior.

Authors:  Nina Buch-Månson; Arnaud Spangenberg; Laura Piedad Chia Gomez; Jean-Pierre Malval; Olivier Soppera; Karen L Martinez
Journal:  Sci Rep       Date:  2017-08-23       Impact factor: 4.379
  2 in total

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