An interoperable pillbox system for smart medication adherence.

We have designed and fabricated an interoperable system for medication adherence. The system is composed of a pillbox that wirelessly communicates with a computer application and a custom-made wristband. The system receives the information of taking specific medication from the user or caregiver, reminds the user to take the medication, monitors the user's hand gesture during the medication intake and monitors the compartments of the pillbox for refilling purpose. The performance of the developed system was examined in various bench-top scenarios. The system has the potential to improve the existing systems by reminding the user to take the medication through the wristband, automatically collecting user's hand gestures during the medication intake, and providing detailed information about the exisexistencetence of medication in the compartments of the pillbox.