Literature DB >> 2557002

Defective phosphorylation of a calmodulin-binding protein in cystic-fibrosis submandibular glands.

D K Shori1, R L Dormer, M C Goodchild, M A McPherson.   

Abstract

Calmodulin-binding proteins in fractions purified from human submandibular glands by calmodulin-Sepharose were phosphorylated with [gamma-32P]ATP, in the absence of exogenous protein kinase. The major proteins phosphorylated had molecular masses of 45, 51 and 61 kDa. Phosphorylation was increased by activators of protein kinase C and inhibited by H-7. Phosphorylation of the 61 kDa band was markedly decreased in cystic-fibrosis submandibular glands.

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Year:  1989        PMID： 2557002      PMCID： PMC1133472          DOI： 10.1042/bj2630613

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients.

Authors:  M A McPherson; R L Dormer; N A Bradbury; J A Dodge; M C Goodchild
Journal:  Lancet       Date:  1986-11-01       Impact factor: 79.321

3.  Phosphorylation of the calmodulin-dependent protein phosphatase by protein kinase C.

Authors:  H Y Tung
Journal:  Biochem Biophys Res Commun       Date:  1986-07-31       Impact factor: 3.575

4.  Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.

Authors:  D K Blumenthal; K Takio; R S Hansen; E G Krebs
Journal:  J Biol Chem       Date:  1986-06-25       Impact factor: 5.157

5.  Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells.

Authors:  R A Schoumacher; R L Shoemaker; D R Halm; E A Tallant; R W Wallace; R A Frizzell
Journal:  Nature       Date:  1987 Dec 24-31       Impact factor: 49.962

6.  Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium.

Authors:  M Li; J D McCann; C M Liedtke; A C Nairn; P Greengard; M J Welsh
Journal:  Nature       Date:  1988-01-28       Impact factor: 49.962

Review 7.  Defective regulation of apical membrane chloride transport and exocytosis in cystic fibrosis.

Authors:  M A McPherson; D K Shori; R L Dormer
Journal:  Biosci Rep       Date:  1988-02       Impact factor: 3.840

Review 8.  The molecular and biochemical basis of cystic fibrosis.

Authors:  M A McPherson; R L Dormer
Journal:  Biosci Rep       Date:  1987-03       Impact factor: 3.840

9.  An altered calmodulin binding protein in cystic fibrosis--a clue to the biochemical defect.

Authors:  D K Shori; N A Bradbury; M C Goodchild; R L Dormer; M A McPherson
Journal:  Clin Chim Acta       Date:  1988-06-15       Impact factor: 3.786

10.  Regulatory interactions of calmodulin-binding proteins: phosphorylation of calcineurin by autophosphorylated Ca2+/calmodulin-dependent protein kinase II.

Authors:  Y Hashimoto; M M King; T R Soderling
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205
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