Literature DB >> 2556981

Destabilization of herpes simplex virus type 1 virions by local anesthetics, alkaline pH, and calcium depletion.

K Yanagi1, S Harada.   

Abstract

The infectivity of herpes simplex virus type 1 (HSV-1) was found to be markedly reduced by treating virions with the tertiary amine local anesthetics lidocaine, dibucaine and tetracaine. These treatments induced a characteristic shift in the buoyant density of the HSV-1 particles from a "light" to a "heavy" population. HSV-1 virions were unstable at alkaline pH, and alkali treatment caused the same shift in buoyant density. Ca2+ stabilized the "light" population. These results suggest that the physicochemical status of the HSV-1 envelope which is sensitive to the treatments described above plays an important role for the integrity of the virion.

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Year:  1989        PMID： 2556981     DOI： 10.1007/BF01313753

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  30 in total

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Authors:  K Wetz; P Willingmann; H Zeichhardt; K O Habermehl
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574

2.  Characterization of type 1 poliovirus by electrophoretic analysis.

Authors:  B Mandel
Journal:  Virology       Date:  1971-06       Impact factor: 3.616

3.  The influence of pH, Ca2+ and protein on the thermotropic behaviour of the negatively charged phospholipid, phosphatidylglycerol.

Authors:  A J Verkleij; B de Kruyff; P H Ververgaert; J F Tocanne; L L van Deenen
Journal:  Biochim Biophys Acta       Date:  1974-03-29

4.  Phospholipid model membranes. 3. Antagonistic effects of Ca2+ and local anesthetics on the permeability of phosphatidylserine vesicles.

Authors:  D Papahadjopoulos
Journal:  Biochim Biophys Acta       Date:  1970-09-15

5.  Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization.

Authors:  E A Emini; P Ostapchuk; E Wimmer
Journal:  J Virol       Date:  1983-11       Impact factor: 5.103

6.  Irreversible conversion of the physical state of herpes simplex virus preceding inactivation by thermal or antibody treatment.

Authors:  K Yanagi
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

7.  Mechanism of action of cytochalasin B on actin.

Authors:  S MacLean-Fletcher; T D Pollard
Journal:  Cell       Date:  1980-06       Impact factor: 41.582

8.  Heterogeneity of vesicular stomatitis virus particles: implications for virion assembly.

Authors:  H F Lodish; M Porter
Journal:  J Virol       Date:  1980-01       Impact factor: 5.103

9.  Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.

Authors:  B Norrild; V P Lehto; I Virtanen
Journal:  J Gen Virol       Date:  1986-01       Impact factor: 3.891

10.  Local anesthetics affect transmembrane cytoskeletal control of mobility and distribution of cell surface receptors.

Authors:  G Poste; D Papahadjopoulos; G L Nicolson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205
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  4 in total

1.  Inhibition of rabies virus transcription in rat cortical neurons with the dissociative anesthetic ketamine.

Authors:  B P Lockhart; N Tordo; H Tsiang
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

2.  Geographical distribution of the herpes simplex virus type 1 BgKL variant in Japan suggests gradual dispersion of the virus from Shikoku Island to the other Islands.

Authors:  Shigeru Ozawa; Hiroyuki Eda; Kozaburo Hayashi; Kamesaburo Yoshino; Kazuo Yanagi
Journal:  J Clin Microbiol       Date:  2006-06       Impact factor: 5.948

3.  Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry.

Authors:  Miriam Triyatni; Bertrand Saunier; Padma Maruvada; Anthony R Davis; Luca Ulianich; Theo Heller; Arvind Patel; Leonard D Kohn; T Jake Liang
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

4.  Involvement of intracellular free Ca2+ in enhanced release of herpes simplex virus by hydrogen peroxide.

Authors:  Emiko Arimoto; Soichi Iwai; Tetsuro Sumi; Yuzo Ogawa; Yoshiaki Yura
Journal:  Virol J       Date:  2006-08-31       Impact factor: 4.099
  4 in total

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