Literature DB >> 25569152

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate.

Stéphane Salamone1, Catherine Guerreiro, Emmanuelle Cambon, Isabelle André, Magali Remaud-Siméon, Laurence A Mulard.   

Abstract

The powerful chemo-enzymatic synthesis of the pentadecasaccharide hapten involved in the first synthetic carbohydrate-based vaccine candidate against endemic shigellosis is reported. The high yielding site-selective α-D-glucosylation of a lightly protected disaccharide by an engineered transglucosylase-sucrose system gave a trisaccharide, which was chemically elongated by an efficient [5+5] process.

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Year:  2015        PMID： 25569152     DOI： 10.1039/c4cc08805k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  GH13 amylosucrases and GH70 branching sucrases, atypical enzymes in their respective families.

Authors:  Claire Moulis; Isabelle André; Magali Remaud-Simeon
Journal:  Cell Mol Life Sci       Date:  2016-05-03       Impact factor: 9.261

Review 2.  Harnessing glycoenzyme engineering for synthesis of bioactive oligosaccharides.

Authors:  Mounir Benkoulouche; Régis Fauré; Magali Remaud-Siméon; Claire Moulis; Isabelle André
Journal:  Interface Focus       Date:  2019-02-15       Impact factor: 3.906

3.  Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides.

Authors:  Shayli Varasteh Moradi; Waleed M Hussein; Pegah Varamini; Pavla Simerska; Istvan Toth
Journal:  Chem Sci       Date:  2016-01-29       Impact factor: 9.825

4.  Combining multi-scale modelling methods to decipher molecular motions of a branching sucrase from glycoside-hydrolase family 70.

Authors:  Akli Ben Imeddourene; Jérémy Esque; Isabelle André
Journal:  PLoS One       Date:  2018-08-01       Impact factor: 3.240

5.  Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides.

Authors:  Mounir Benkoulouche; Akli Ben Imeddourene; Louis-Antoine Barel; Dorian Lefebvre; Mathieu Fanuel; Hélène Rogniaux; David Ropartz; Sophie Barbe; David Guieysse; Laurence A Mulard; Magali Remaud-Siméon; Claire Moulis; Isabelle André
Journal:  Sci Rep       Date:  2021-10-13       Impact factor: 4.379

6.  The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella.

Authors:  Robert M F van der Put; Carolien Smitsman; Alex de Haan; Martin Hamzink; Hans Timmermans; Joost Uittenbogaard; Janny Westdijk; Michiel Stork; Olga Ophorst; Françoise Thouron; Catherine Guerreiro; Philippe J Sansonetti; Armelle Phalipon; Laurence A Mulard
Journal:  ACS Cent Sci       Date:  2022-03-17       Impact factor: 18.728

Review 7.  Biocatalyzed Synthesis of Glycostructures with Anti-infective Activity.

Authors:  Pilar Hoyos; Almudena Perona; Teodora Bavaro; Francesca Berini; Flavia Marinelli; Marco Terreni; María J Hernáiz
Journal:  Acc Chem Res       Date:  2022-08-09       Impact factor: 24.466

Review 8.  Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges.

Authors:  Armelle Phalipon; Laurence A Mulard
Journal:  Vaccines (Basel)       Date:  2022-03-07
  8 in total

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