Literature DB >> 25568610

EFFECT OF TYPE 2 DIABETES MELLITUS ON BRAIN METABOLITES BY USING PROTON MAGNETIC RESONANCE SPECTROSCOPY-A SYSTEMATIC REVIEW.

Rajani Santhakumari1, Indla Yogananda Reddy1, R Archana2.   

Abstract

Cerebral metabolism will be affected in T2DM either by chronic hyperglycemia or by chronic hypoxia. Proton magnetic resonance spectroscopy (1H-MRS) of the brain provides detailed information about the structure, dynamics, reaction state and chemical environment of molecules. It also measures the levels of brain metabolites such as myo-inositol (mI), N acetyl aspartate (NAA), creatine (Cr), choline (Cho), glutamate (Glu), glutamine (Gln) and gamma amino butyric acid (GABA). Several studies suggest that people with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive impairment in comparison with the general population. The altered metabolites may cause cognitive dysfunction in T2DM. This review article concludes that in T2DM, metabolite levels were altered in different regions of brain.

Entities:  

Keywords:  Brain metabolites; Cognition; Proton Magnetic Resonance Spectroscopy of brain; Type 2 diabetes mellitus

Year:  2014        PMID： 25568610      PMCID： PMC4283136     

Source DB:  PubMed          Journal:  Int J Pharma Bio Sci        ISSN： 0975-6299


  28 in total

1.  Diabetes, cognitive impairment, and dementia.

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Journal:  BMJ       Date:  2008-01-05

Review 2.  Brain proton magnetic resonance spectroscopy: introduction and overview.

Authors:  Débora Bertholdo; Arvemas Watcharakorn; Mauricio Castillo
Journal:  Neuroimaging Clin N Am       Date:  2013-01-20       Impact factor: 2.264

3.  Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy.

Authors:  Elizabeth R Seaquist; Ivan Tkac; Greg Damberg; William Thomas; Rolf Gruetter
Journal:  Metabolism       Date:  2005-08       Impact factor: 8.694

4.  Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes.

Authors:  Po Lai Yau; David Javier; Wai Tsui; Victoria Sweat; Hannah Bruehl; Joan C Borod; Antonio Convit
Journal:  Psychiatry Res       Date:  2009-11-10       Impact factor: 3.222

5.  Metabolite differences in the lenticular nucleus in type 2 diabetes mellitus shown by proton MR spectroscopy.

Authors:  Y Lin; J Zhou; L Sha; Y Li; X Qu; L Liu; H Chen; Z An; Y Wang; C Sun
Journal:  AJNR Am J Neuroradiol       Date:  2013-04-18       Impact factor: 3.825

6.  Brain metabolite changes in patients with type 2 diabetes and cerebral infarction using proton magnetic resonance spectroscopy.

Authors:  Min Zhang; Xinhai Sun; Zhengjun Zhang; Qiang Meng; Yuzhong Wang; Jing Chen; Xueqin Ma; Houfa Geng; Lin Sun
Journal:  Int J Neurosci       Date:  2013-11-19       Impact factor: 2.292

Review 7.  Diabetic neuropathies.

Authors:  A I Vinik; M T Holland; J M Le Beau; F J Liuzzi; K B Stansberry; L B Colen
Journal:  Diabetes Care       Date:  1992-12       Impact factor: 19.112

Review 8.  Cerebral function in diabetes mellitus.

Authors:  G J Biessels; A C Kappelle; B Bravenboer; D W Erkelens; W H Gispen
Journal:  Diabetologia       Date:  1994-07       Impact factor: 10.122

9.  Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy.

Authors:  A Geissler; R Fründ; J Schölmerich; S Feuerbach; B Zietz
Journal:  Exp Clin Endocrinol Diabetes       Date:  2003-10       Impact factor: 2.949

10.  Relationships among serum C-reactive protein, receptor for advanced glycation products, metabolic dysfunction, and cognitive impairments.

Authors:  Xia Ge; Xiao-yun Xu; Chun-hua Feng; Yue Wang; Yuan-ling Li; Bo Feng
Journal:  BMC Neurol       Date:  2013-08-27       Impact factor: 2.474
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  7 in total

1.  ROLE OF YOGA ON CARDIC AUTONOMIC FUNCTION TESTS AND COGNITION IN TYPE 2 DIABETES.

Authors:  Santhakumari Nagothu Rajani; Yogananda Reddy Indla; R Archana; P Rajesh
Journal:  Int J Res Ayurveda Pharm       Date:  2015 Nov-Dec

2.  Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits.

Authors:  Peter J Fried; Lukas Schilberg; Anna-Katharine Brem; Sadhvi Saxena; Bonnie Wong; Aaron M Cypess; Edward S Horton; Alvaro Pascual-Leone
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

Review 3.  Diabetes and Cognitive Impairment.

Authors:  Lindsay A Zilliox; Krish Chadrasekaran; Justin Y Kwan; James W Russell
Journal:  Curr Diab Rep       Date:  2016-09       Impact factor: 4.810

4.  Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy.

Authors:  Rajani Santhakumari Nagothu; Yogananda Indla Reddy; Archana Rajagopalan; Ravi Varma
Journal:  J Clin Diagn Res       Date:  2015-07-01

5.  Beneficial Effects of Yogasanas and Pranayama in limiting the Cognitive decline in Type 2 Diabetes.

Authors:  Santhakumari Rajani; Rajagopalan Archana; Yogananda Reddy Indla; P Rajesh
Journal:  Natl J Physiol Pharm Pharmacol       Date:  2016-09-24

6.  Hyperglycemia and hyperinsulinemia effects on anterior cingulate cortex myoinositol-relation to brain network functional connectivity in healthy adults.

Authors:  Nicolas R Bolo; Alan M Jacobson; Gail Musen; Donald C Simonson
Journal:  J Neurophysiol       Date:  2022-04-13       Impact factor: 2.974

Review 7.  Pancreatic imaging: Current status of clinical practices and small animal studies.

Authors:  Ting Yin; Yewei Liu; Ronald Peeters; Yuanbo Feng; Yicheng Ni
Journal:  World J Methodol       Date:  2017-09-26
  7 in total

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