Literature DB >> 2556851

Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs.

S R Turk1, N A Kik, G M Birch, D J Chiego, C Shipman.   

Abstract

Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.

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Year:  1989        PMID： 2556851     DOI： 10.1016/0042-6822(89)90588-6

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  4 in total

Review 1.  Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors:  Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal:  Chem Rev       Date:  2014-10-02       Impact factor: 60.622

2.  The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.

Authors:  P Desai; R Ramakrishnan; Z W Lin; B Osak; J C Glorioso; M Levine
Journal:  J Virol       Date:  1993-10       Impact factor: 5.103

3.  Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats.

Authors:  M G Kaplitt; J G Tjuvajev; D A Leib; J Berk; K D Pettigrew; J B Posner; D W Pfaff; S D Rabkin; R G Blasberg
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

4.  Sequences of the ribonucleotide reductase-encoding genes of felid herpesvirus 1 and molecular phylogenetic analysis.

Authors:  K Willoughby; M Bennett; R A Williams; C McCracken; R M Gaskell
Journal:  Virus Genes       Date:  1997       Impact factor: 2.198
  4 in total

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