Literature DB >> 25567100

Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor.

Ryan E Cobb1, Brian Bae, Zhi Li, Matthew A DeSieno, Satish K Nair, Huimin Zhao.   

Abstract

We report here the enzymatic biosynthesis of FR-900098 analogues and establish an in vivo platform for the biosynthesis of an N-propionyl derivative FR-900098P. FR-900098P is found to be a significantly more potent inhibitor of Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase (PfDxr) than the parent compound, and thus a more promising antimalarial drug candidate.

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Year:  2015        PMID： 25567100      PMCID： PMC4312176          DOI： 10.1039/c4cc09181g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

1.  Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

Authors:  Ronan Jambou; Eric Legrand; Makhtar Niang; Nimol Khim; Pharath Lim; Béatrice Volney; Marie Thérèse Ekala; Christiane Bouchier; Philippe Esterre; Thierry Fandeur; Odile Mercereau-Puijalon
Journal:  Lancet       Date:  2005-12-03       Impact factor: 79.321

2.  Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors.

Authors:  Timothy Haemers; Jochen Wiesner; Sara Van Poecke; Jan Goeman; Dajana Henschker; Edwald Beck; Hassan Jomaa; Serge Van Calenbergh
Journal:  Bioorg Med Chem Lett       Date:  2006-01-24       Impact factor: 2.823

3.  Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity.

Authors:  Jochen Wiesner; Regina Ortmann; Hassan Jomaa; Martin Schlitzer
Journal:  Arch Pharm (Weinheim)       Date:  2007-12       Impact factor: 3.751

4.  Evidence of artemisinin-resistant malaria in western Cambodia.

Authors:  Harald Noedl; Youry Se; Kurt Schaecher; Bryan L Smith; Duong Socheat; Mark M Fukuda
Journal:  N Engl J Med       Date:  2008-12-08       Impact factor: 91.245

5.  DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.

Authors:  Anna M Jansson; Anna Więckowska; Christofer Björkelid; Samir Yahiaoui; Sanjeewani Sooriyaarachchi; Martin Lindh; Terese Bergfors; Shyamraj Dharavath; Matthieu Desroses; Surisetti Suresh; Mounir Andaloussi; Rautela Nikhil; Sharma Sreevalli; Bachally R Srinivasa; Mats Larhed; T Alwyn Jones; Anders Karlén; Sherry L Mowbray
Journal:  J Med Chem       Date:  2013-07-17       Impact factor: 7.446

Review 6.  Management of malaria: recent trends.

Authors:  S R Mehta; S Das
Journal:  J Commun Dis       Date:  2006-03

Review 7.  Isoprenoid biosynthesis of the apicoplast as drug target.

Authors:  Jochen Wiesner; Hassan Jomaa
Journal:  Curr Drug Targets       Date:  2007-01       Impact factor: 3.465

Review 8.  1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview.

Authors:  Philip J Proteau
Journal:  Bioorg Chem       Date:  2004-12       Impact factor: 5.275

9.  Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.

Authors:  Lionel Kuntz; Denis Tritsch; Catherine Grosdemange-Billiard; Andréa Hemmerlin; Audrey Willem; Thomas J Bach; Michel Rohmer
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857

10.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245
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  1 in total

Review 1.  Molecular docking as a popular tool in drug design, an in silico travel.

Authors:  Jerome de Ruyck; Guillaume Brysbaert; Ralf Blossey; Marc F Lensink
Journal:  Adv Appl Bioinform Chem       Date:  2016-06-28
  1 in total

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