Literature DB >> 25566939

Excessive fragmentary myoclonus in patients with Parkinson's disease: prevalence and clinico-polysomnographic profile.

Manoel Alves Sobreira-Neto1, Márcio Alexandre Pena-Pereira, Emmanuelle Silva Tavares Sobreira, Marcos Hortes Nisihara Chagas, Vitor Tumas, Regina Maria França Fernandes, Alan Luiz Eckeli.   

Abstract

OBJECTIVE AND
BACKGROUND: Excessive fragmentary myoclonus (EFM) is characterized by subtle arrhythmic and excessive jerks that are usually asymmetric and asynchronous. EFM occurs in different areas of the body, mainly the face and distal parts of the arms and legs, and is detected by surface electromyography during sleep. The present study aimed to determine the prevalence of EFM in Parkinson's disease (PD) patients at a tertiary level outpatient clinic as well as to describe the clinical and polysomnographic profiles of these patients.
METHODS: A total of 62 consecutive PD patients were included in the study. Patients were evaluated using the Brazilian version of the PD Sleep Scale, Portuguese Language version of Epworth's Daytime Sleepiness Scale validated for Brazilian population, Brazilian Portuguese version of PD Quality of Life Scale, and Global Deterioration Scale. Evaluation of the sleep disorders was performed by clinical interview and polysomnography.
RESULTS: EFM was found in 62.7% of PD patients. EFM was found to be associated with obstructive sleep apnea syndrome and advanced age.
CONCLUSIONS: EFM occurs in a significantly high proportion of PD patients and is related to obstructive sleep apnea syndrome (OSAS) and advanced age, so EFM should be systematically investigated by polysomnography (PSG) in PD patients.

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Year:  2015        PMID: 25566939     DOI: 10.1007/s11325-014-1098-2

Source DB:  PubMed          Journal:  Sleep Breath        ISSN: 1520-9512            Impact factor:   2.816


  15 in total

1.  Test-retest reliability of UPDRS-III, dyskinesia scales, and timed motor tests in patients with advanced Parkinson's disease: an argument against multiple baseline assessments.

Authors:  Leo Verhagen Metman; Brian Myre; Niek Verwey; Sharon Hassin-Baer; Jean Arzbaecher; Diane Sierens; Roy Bakay
Journal:  Mov Disord       Date:  2004-09       Impact factor: 10.338

2.  Excessive fragmentary hypnic myoclonus in a patient affected by a mitochondrial encephalomyopathy.

Authors:  Alessandro Pincherle; Luca Mantoani; Flavio Villani; Paolo Confalonieri; Alessandra Erbetta
Journal:  Sleep Med       Date:  2006-11-13       Impact factor: 3.492

3.  Psychometric properties of the Parkinson's Disease Sleep Scale--Brazilian version.

Authors:  Regina Margis; Karina Donis; Suzana Veiga Schönwald; Simone Chaves Fagondes; Thais Monte; Pablo Martín-Martínez; K Ray Chaudhuri; Flávio Kapczinski; Carlos R M Rieder
Journal:  Parkinsonism Relat Disord       Date:  2009-02-10       Impact factor: 4.891

4.  A putative flip-flop switch for control of REM sleep.

Authors:  Jun Lu; David Sherman; Marshall Devor; Clifford B Saper
Journal:  Nature       Date:  2006-05-10       Impact factor: 49.962

5.  Fragmentary myoclonus in sleep revisited: a polysomnographic study in 62 patients.

Authors:  Birgit Frauscher; Alexander Kunz; Elisabeth Brandauer; Hanno Ulmer; Werner Poewe; Birgit Högl
Journal:  Sleep Med       Date:  2011-04       Impact factor: 3.492

6.  Excessive fragmentary hypnic myoclonus: clinical and neurophysiological findings.

Authors:  Roberto Vetrugno; Giuseppe Plazzi; Federica Provini; Rocco Liguori; Elio Lugaresi; Pasquale Montagna
Journal:  Sleep Med       Date:  2002-01       Impact factor: 3.492

Review 7.  Stages in the development of Parkinson's disease-related pathology.

Authors:  Heiko Braak; Estifanos Ghebremedhin; Udo Rüb; Hansjürgen Bratzke; Kelly Del Tredici
Journal:  Cell Tissue Res       Date:  2004-08-24       Impact factor: 5.249

8.  Excessive fragmentary myoclonus in NREM sleep: a report of 38 cases.

Authors:  R Broughton; M A Tolentino; M Krelina
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1985-08

9.  Portuguese-language version of the Epworth sleepiness scale: validation for use in Brazil.

Authors:  Alessandra Naimaier Bertolazi; Simone Chaves Fagondes; Leonardo Santos Hoff; Vinícius Dallagasperina Pedro; Sérgio Saldanha Menna Barreto; Murray W Johns
Journal:  J Bras Pneumol       Date:  2009-09       Impact factor: 2.624

10.  Fragmentary pathological myoclonus in NREM sleep.

Authors:  R Broughton; M A Tolentino
Journal:  Electroencephalogr Clin Neurophysiol       Date:  1984-04
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