BACKGROUND AND PURPOSE: To determine baseline volume and rate of volume change of whole brain, hippocampus, and entorhinal cortex in patients with atrial fibrillation. METHODS: We analyzed clinical and neuroimaging data collected as part of Alzheimer's Disease Neuroimaging Initiative in the United States and Canada. Patients with atrial fibrillation were identified based on baseline clinical/cognitive assessments, and age and gender-matched controls without atrial fibrillations were selected (1:1 ratio). All participants underwent 1.5 T structural magnetic resonance imaging (MRI) at specified intervals (6 or 12 months) for 2-3 years. RESULTS: A total of 33 persons with atrial fibrillation were included. There was no difference in whole brain and ventricular volumes at baseline MRI between cases and controls. There was significantly lower entorhinal cortex volume on right (p = 0.01) and left (p = 0.01) sides in patients with atrial fibrillation. There was significantly lower volume for middle temporal lobes on right (p = 0.04) and left (p = 0.001) sides. The rate of progression of atrophy in entorhinal cortex and middle temporal lobes was not different between patients with atrial fibrillation and controls. CONCLUSIONS: The association of atrial fibrillation with volume loss in entorhinal cortex and middle temporal lobes may provide new insights into pathophysiology of atrial fibrillation.
BACKGROUND AND PURPOSE: To determine baseline volume and rate of volume change of whole brain, hippocampus, and entorhinal cortex in patients with atrial fibrillation. METHODS: We analyzed clinical and neuroimaging data collected as part of Alzheimer's Disease Neuroimaging Initiative in the United States and Canada. Patients with atrial fibrillation were identified based on baseline clinical/cognitive assessments, and age and gender-matched controls without atrial fibrillations were selected (1:1 ratio). All participants underwent 1.5 T structural magnetic resonance imaging (MRI) at specified intervals (6 or 12 months) for 2-3 years. RESULTS: A total of 33 persons with atrial fibrillation were included. There was no difference in whole brain and ventricular volumes at baseline MRI between cases and controls. There was significantly lower entorhinal cortex volume on right (p = 0.01) and left (p = 0.01) sides in patients with atrial fibrillation. There was significantly lower volume for middle temporal lobes on right (p = 0.04) and left (p = 0.001) sides. The rate of progression of atrophy in entorhinal cortex and middle temporal lobes was not different between patients with atrial fibrillation and controls. CONCLUSIONS: The association of atrial fibrillation with volume loss in entorhinal cortex and middle temporal lobes may provide new insights into pathophysiology of atrial fibrillation.
Entities:
Keywords:
Atrial fibrillation; entorhinal cortex; magnetic resonance imaging (MRI); temporal lobe; volume loss
Authors: Stefan Knecht; Christian Oelschläger; Thomas Duning; Hubertus Lohmann; Johannes Albers; Christoph Stehling; Walter Heindel; Günter Breithardt; Klaus Berger; E Bernd Ringelstein; Paulus Kirchhof; Heike Wersching Journal: Eur Heart J Date: 2008-07-29 Impact factor: 29.983
Authors: Manuela Polydoro; Alix de Calignon; Marc Suárez-Calvet; Laura Sanchez; Kevin R Kay; Samantha B Nicholls; Allyson D Roe; Rose Pitstick; George A Carlson; Teresa Gómez-Isla; Tara L Spires-Jones; Bradley T Hyman Journal: J Neurosci Date: 2013-08-14 Impact factor: 6.167
Authors: Hanna Ansakorpi; Juha T Korpelainen; Kalervo Suominen; Uolevi Tolonen; Risto Bloigu; Vilho V Myllylä; Jouko I T Isojärvi Journal: Neurol Res Int Date: 2011-07-14
Authors: Gargi Banerjee; Edgar Chan; Gareth Ambler; Duncan Wilson; Lisa Cipolotti; Clare Shakeshaft; Hannah Cohen; Tarek Yousry; Rustam Al-Shahi Salman; Gregory Y H Lip; Keith W Muir; Martin M Brown; Hans Rolf Jäger; David J Werring Journal: J Am Heart Assoc Date: 2020-01-04 Impact factor: 5.501