Literature DB >> 25564252

Role of microRNA 21 in mesenchymal stem cell (MSC) differentiation: a powerful biomarker in MSCs derived cells.

Durairaj Sekar, Subramanian Saravanan, Kulandaivelu Karikalan, Krishnaraj Thirugnanasambantham, Perumal Lalitha, Villianur I H Islam1.   

Abstract

The significant role of microRNAs (miRNAs) in stem cell development has been expansively discussed in recent publications and they are noticed to be involved in post transcriptional regulation of gene expression by its affinity towards the 3'UTR of target mRNA. Since the expression of miR-21 was high in cells that were derived from MSCs, recent evidence indicates that miR-21 plays a vital role in mesenchymal stem cells (MSCs) differentiation. Despite the fact that miR-21 can be considered as a powerful biomarker for MSCs differentiation, the number of studies related to the above scenario is very limited. This review highlights the recent publications related to the importance of miR-21 specifically in differentiation of MSCs.

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Year:  2015        PMID： 25564252     DOI： 10.2174/138920101601150105100851

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN： 1389-2010            Impact factor:   2.837


  9 in total

1.  Expression and methylation of circulating microRNA-510 in essential hypertension.

Authors:  Ramalingam Krishnan; Panagal Mani; Pethanen Sivakumar; Vincent Gopinath; Durairaj Sekar
Journal:  Hypertens Res       Date:  2016-11-24       Impact factor: 3.872

2.  Altered expression of circular RNAs in human placental chorionic plate-derived mesenchymal stem cells pretreated with hypoxia.

Authors:  Xunsha Sun; Yulin Jin; Qihua Liang; Jie Tang; Jinsong Chen; Qiuxia Yu; Fatao Li; Yan Li; Jieying Wu; Shaoqing Wu
Journal:  J Clin Lab Anal       Date:  2018-11-28       Impact factor: 2.352

3.  MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects.

Authors:  Valeria Guglielmi; Monica D'Adamo; Rossella Menghini; Marina Cardellini; Paolo Gentileschi; Massimo Federici; Paolo Sbraccia
Journal:  Nutr Healthy Aging       Date:  2017-03-31

Review 4.  Emerging Evidence of Epigenetic Modifications in Vascular Complication of Diabetes.

Authors:  Madhu Khullar; Balneek Singh Cheema; Satish K Raut
Journal:  Front Endocrinol (Lausanne)       Date:  2017-09-29       Impact factor: 5.555

5.  Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma.

Authors:  Hamideh Monfared; Yavar Jahangard; Maryam Nikkhah; Javad Mirnajafi-Zadeh; Seyed Javad Mowla
Journal:  Front Oncol       Date:  2019-08-20       Impact factor: 6.244

Review 6.  Micro-RNAs: A safety net to protect hematopoietic stem cell self-renewal.

Authors:  Laura Crisafulli; Francesca Ficara
Journal:  Wiley Interdiscip Rev RNA       Date:  2021-09-16       Impact factor: 9.349

Review 7.  Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment.

Authors:  Lifang Hu; Chong Yin; Fan Zhao; Arshad Ali; Jianhua Ma; Airong Qian
Journal:  Int J Mol Sci       Date:  2018-01-25       Impact factor: 5.923

Review 8.  Deciphering the role of microRNA 21 in cancer stem cells (CSCs).

Authors:  Durairaj Sekar; Ramalingam Krishnan; Mani Panagal; Pethanen Sivakumar; Vincent Gopinath; Venugopal Basam
Journal:  Genes Dis       Date:  2016-06-24

Review 9.  Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis.

Authors:  Amir B Ghaemmaghami; Maryam Mahjoubin-Tehran; Ahmad Movahedpour; Korosh Morshedi; Amirhossein Sheida; Seyed Pouya Taghavi; Hamed Mirzaei; Michael R Hamblin
Journal:  Cell Commun Signal       Date:  2020-08-03       Impact factor: 7.525
  9 in total

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