Vandana Kaul1, Sheri Krams. 1. Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Abstract
PURPOSE OF REVIEW: MicroRNAs (miRNAs) have emerged as highly evolutionarily conserved moieties that have very selective gene-regulatory functions. miRNAs are being researched for their use as potential biomarkers for diagnostics, routine prognostics as well as selective therapeutics in cancer, infectious diseases, autoimmune disorders and transplantation. This review summarizes how immune regulation by miRNAs affects the outcome of transplantation. RECENT FINDINGS: Many miRNAs have been identified as selective markers for specific disease states and transplant conditions in the past two decades. In this review, we will discuss the recent advances and some seminal discoveries in miRNA research and their role as immune regulators in transplantation. Lastly, we will highlight the ongoing clinical trials for miRNA-based therapeutics for clinical applications and present our opinion on the future of miRNA-based diagnostics and therapeutics. SUMMARY: miRNA-based diagnosis is a fast-moving field with new miRNA signatures being identified each day. Recent advances have also been successful at taking a few of these miRNAs to clinical trials for therapeutic interventions.
PURPOSE OF REVIEW: MicroRNAs (miRNAs) have emerged as highly evolutionarily conserved moieties that have very selective gene-regulatory functions. miRNAs are being researched for their use as potential biomarkers for diagnostics, routine prognostics as well as selective therapeutics in cancer, infectious diseases, autoimmune disorders and transplantation. This review summarizes how immune regulation by miRNAs affects the outcome of transplantation. RECENT FINDINGS: Many miRNAs have been identified as selective markers for specific disease states and transplant conditions in the past two decades. In this review, we will discuss the recent advances and some seminal discoveries in miRNA research and their role as immune regulators in transplantation. Lastly, we will highlight the ongoing clinical trials for miRNA-based therapeutics for clinical applications and present our opinion on the future of miRNA-based diagnostics and therapeutics. SUMMARY: miRNA-based diagnosis is a fast-moving field with new miRNA signatures being identified each day. Recent advances have also been successful at taking a few of these miRNAs to clinical trials for therapeutic interventions.
Authors: Matthew James Vitalone; Liang Wei; Masato Fujiki; Audrey H Lau; Erik Littau; Carlos Esquivel; Olivia M Martinez; Sheri M Krams Journal: Transplantation Date: 2016-04 Impact factor: 4.939
Authors: Thangamani Muthukumar; Kemal M Akat; Hua Yang; Joseph E Schwartz; Carol Li; Heejung Bang; Iddo Z Ben-Dov; John R Lee; David Ikle; Anthony J Demetris; Thomas Tuschl; Manikkam Suthanthiran Journal: Transplantation Date: 2022-04-01 Impact factor: 4.939
Authors: Olivia Hatton; Madeline M Smith; Madison Alexander; Melanie Mandell; Carissa Sherman; Madeline W Stesney; Sin Ting Hui; Gillian Dohrn; Joselinne Medrano; Kurt Ringwalt; Aleishia Harris-Arnold; Eden M Maloney; Sheri M Krams; Olivia M Martinez Journal: Front Microbiol Date: 2019-11-26 Impact factor: 5.640