Literature DB >> 2556346

Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain.

M N Woodroofe1, G M Hayes, M L Cuzner.   

Abstract

Treatment of microglia isolated from adult rat brain with interferon-gamma (IFN-gamma) at a concentration of 1 U/ml resulted in enhanced expression of Fc receptors and major histocompatibility complex (MHC) antigens and increased production of superoxide anions. Neonatal microglia and peritoneal macrophages, isolated and cultured in the same manner, displayed functional properties very similar to those of adult microglia, indicating a common origin for different macrophage populations. The Fc binding capacity of microglia was found to be significantly greater than that of peritoneal cells, thus underlining the potential role of microglia in immune-mediated demyelination.

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Year:  1989        PMID： 2556346      PMCID： PMC1385458     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  13 in total

1.  Production of superoxide anions by a CNS macrophage, the microglia.

Authors:  C A Colton; D L Gilbert
Journal:  FEBS Lett       Date:  1987-11-02       Impact factor: 4.124

2.  The purification and characterization of rat gamma interferon by use of two monoclonal antibodies.

Authors:  P H van der Meide; M Dubbeld; K Vijverberg; T Kos; H Schellekens
Journal:  J Gen Virol       Date:  1986-06       Impact factor: 3.891

3.  In situ Ia expression on brain cells in the rat: autoimmune encephalomyelitis-resistant strain (BN) and susceptible strain (Lewis) compared.

Authors:  Y Matsumoto; K Kawai; M Fujiwara
Journal:  Immunology       Date:  1989-04       Impact factor: 7.397

4.  Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

Authors:  F M Hofman; R I von Hanwehr; C A Dinarello; S B Mizel; D Hinton; J E Merrill
Journal:  J Immunol       Date:  1986-05-01       Impact factor: 5.422

5.  Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

Authors:  Y Matsumoto; N Hara; R Tanaka; M Fujiwara
Journal:  J Immunol       Date:  1986-05-15       Impact factor: 5.422

6.  Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain.

Authors:  V H Perry; D A Hume; S Gordon
Journal:  Neuroscience       Date:  1985-06       Impact factor: 3.590

7.  Microglia are the major cell type expressing MHC class II in human white matter.

Authors:  G M Hayes; M N Woodroofe; M L Cuzner
Journal:  J Neurol Sci       Date:  1987-08       Impact factor: 3.181

8.  A rapid and sensitive method allowing photometric determination of erythrophagocytosis by mononuclear phagocytes.

Authors:  T W Jungi
Journal:  J Immunol Methods       Date:  1985-09-03       Impact factor: 2.303

9.  Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques.

Authors:  J W Prineas; E E Kwon; E S Cho; L R Sharer
Journal:  Ann N Y Acad Sci       Date:  1984       Impact factor: 5.691

10.  Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells.

Authors:  K Frei; C Siepl; P Groscurth; S Bodmer; C Schwerdel; A Fontana
Journal:  Eur J Immunol       Date:  1987-09       Impact factor: 5.532
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  16 in total

Review 1.  Histocompatibility antigens and natural killer susceptibility.

Authors:  J Peña; R Solana
Journal:  Immunol Res       Date:  1992       Impact factor: 2.829

Review 2.  Involvement of Fc receptors in disorders of the central nervous system.

Authors:  Eitan Okun; Mark P Mattson; Thiruma V Arumugam
Journal:  Neuromolecular Med       Date:  2009-10-21       Impact factor: 3.843

Review 3.  The role of macrophage subpopulations in autoimmune disease of the central nervous system.

Authors:  J Bauer; S R Ruuls; I Huitinga; C D Dijkstra
Journal:  Histochem J       Date:  1996-02

Review 4.  Glial lineages and myelination in the central nervous system.

Authors:  A Compston; J Zajicek; J Sussman; A Webb; G Hall; D Muir; C Shaw; A Wood; N Scolding
Journal:  J Anat       Date:  1997-02       Impact factor: 2.610

5.  Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia.

Authors:  A O Caggiano; R P Kraig
Journal:  J Neurochem       Date:  1998-06       Impact factor: 5.372

6.  Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis.

Authors:  M Deckert-Schlüter; H Bluethmann; N Kaefer; A Rang; D Schlüter
Journal:  Am J Pathol       Date:  1999-05       Impact factor: 4.307

Review 7.  Microglia activation and anti-inflammatory regulation in Alzheimer's disease.

Authors:  Lih-Fen Lue; Yu-Min Kuo; Thomas Beach; Douglas G Walker
Journal:  Mol Neurobiol       Date:  2010-03-03       Impact factor: 5.590

8.  B7 costimulatory ligand regulates development of the T-cell response to Cryptococcus neoformans.

Authors:  C Monari; T R Kozel; A Casadevall; D Pietrella; B Palazzetti; A Vecchiarelli
Journal:  Immunology       Date:  1999-09       Impact factor: 7.397

9.  Dynamics of actin filaments in microglia during Fc receptor-mediated phagocytosis.

Authors:  E M Abd-el-Basset; S Fedoroff
Journal:  Acta Neuropathol       Date:  1994       Impact factor: 17.088

10.  Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation.

Authors:  A J Loughlin; M N Woodroofe; M L Cuzner
Journal:  Immunology       Date:  1992-01       Impact factor: 7.397
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