Charlotte H W Wijers1, Iris A L M van Rooij, Roxana Rassouli, Marc H Wijnen, Paul M A Broens, Cornelius E J Sloots, Han G Brunner, Ivo de Blaauw, Nel Roeleveld. 1. From the aDepartment for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands; bDepartment of Pediatric Surgery, Radboud university medical center, Nijmegen, The Netherlands; cDepartment of Surgery, Division of Pediatric Surgery, university medical center Groningen, Groningen, The Netherlands; dDepartment of Pediatric Surgery, Sophia Children's Hospital-Erasmus Medical Centre, Rotterdam, The Netherlands; eDepartment of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands; and fDepartment of Pediatrics, Radboud university medical center, Nijmegen, The Netherlands.
Abstract
BACKGROUND: Fertility treatment seems to play a role in the etiology of congenital anorectal malformations, but it is unclear whether the underlying parental subfertility, ovulation induction, or the treatment itself is involved. Therefore, we investigated the odds of anorectal malformations among children of subfertile parents who conceived with or without treatment compared with fertile parents. METHODS: We performed a case-control study among 380 cases with anorectal malformations treated at 3 departments of pediatric surgery in The Netherlands and 1973 population-based controls born between August 1988 and August 2012. Parental questionnaires were used to obtain information on fertility-related issues and potential confounders. RESULTS: In singletons, increased risks of anorectal malformations were observed for parents who underwent intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) treatment compared with fertile parents (odds ratio = 2.4 [95% confidence interval = 1.0-5.9] and 4.2 [1.9-8.9], respectively). For subfertile parents who conceived after IVF treatment, an elevated risk was also found when they were compared with subfertile parents who conceived without treatment (3.2 [1.4-7.2]). Among children of the latter category of parents, only the risk of anorectal malformations with other major congenital malformations was increased compared with fertile parents (2.0 [1.3-3.3]). No associations were found with intrauterine insemination or use of hormones for ovulation induction. CONCLUSIONS: We found evidence of a role of ICSI and IVF treatments in the etiology of anorectal malformations. However, subfertility without treatment increased only the risk of anorectal malformations with additional congenital malformations.
BACKGROUND: Fertility treatment seems to play a role in the etiology of congenital anorectal malformations, but it is unclear whether the underlying parental subfertility, ovulation induction, or the treatment itself is involved. Therefore, we investigated the odds of anorectal malformations among children of subfertile parents who conceived with or without treatment compared with fertile parents. METHODS: We performed a case-control study among 380 cases with anorectal malformations treated at 3 departments of pediatric surgery in The Netherlands and 1973 population-based controls born between August 1988 and August 2012. Parental questionnaires were used to obtain information on fertility-related issues and potential confounders. RESULTS: In singletons, increased risks of anorectal malformations were observed for parents who underwent intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) treatment compared with fertile parents (odds ratio = 2.4 [95% confidence interval = 1.0-5.9] and 4.2 [1.9-8.9], respectively). For subfertile parents who conceived after IVF treatment, an elevated risk was also found when they were compared with subfertile parents who conceived without treatment (3.2 [1.4-7.2]). Among children of the latter category of parents, only the risk of anorectal malformations with other major congenital malformations was increased compared with fertile parents (2.0 [1.3-3.3]). No associations were found with intrauterine insemination or use of hormones for ovulation induction. CONCLUSIONS: We found evidence of a role of ICSI and IVF treatments in the etiology of anorectal malformations. However, subfertility without treatment increased only the risk of anorectal malformations with additional congenital malformations.
Authors: Rebecca F Liberman; Kelly D Getz; Dominique Heinke; Barbara Luke; Judy E Stern; Eugene R Declercq; Xiaoli Chen; Angela E Lin; Marlene Anderka Journal: Birth Defects Res Date: 2017-06-21 Impact factor: 2.344
Authors: Romy van de Putte; Iris A L M van Rooij; Cynthia P Haanappel; Carlo L M Marcelis; Han G Brunner; Marie-Claude Addor; Clara Cavero-Carbonell; Carlos M Dias; Elizabeth S Draper; Larraitz Etxebarriarteun; Miriam Gatt; Babak Khoshnood; Agnieszka Kinsner-Ovaskainen; Kari Klungsoyr; Jenny J Kurinczuk; Anna Latos-Bielenska; Karen Luyt; Mary T O'Mahony; Nicola Miller; Carmel Mullaney; Vera Nelen; Amanda J Neville; Isabelle Perthus; Anna Pierini; Hanitra Randrianaivo; Judith Rankin; Anke Rissmann; Florence Rouget; Bruno Schaub; David Tucker; Diana Wellesley; Awi Wiesel; Natalya Zymak-Zakutnia; Maria Loane; Ingeborg Barisic; Hermien E K de Walle; Jorieke E H Bergman; Nel Roeleveld Journal: Birth Defects Res Date: 2020-04-22 Impact factor: 2.344
Authors: Mark A Taylor; Brian T Bucher; Ron W Reeder; Marc Levitt; Jeffrey Avansino; Megan M Durham; Casey M Calkins; Richard Wood; Kaylea Drake; Michael Rollins Journal: Cureus Date: 2020-06-22
Authors: Romy van de Putte; Charlotte H W Wijers; Heiko Reutter; Sita H Vermeulen; Carlo L M Marcelis; Erwin Brosens; Paul M A Broens; Markus Homberg; Michael Ludwig; Ekkehart Jenetzky; Nadine Zwink; Cornelius E J Sloots; Annelies de Klein; Alice S Brooks; Robert M W Hofstra; Sophie A C Holsink; Loes F M van der Zanden; Tessel E Galesloot; Paul Kwong-Hang Tam; Marloes Steehouwer; Rocio Acuna-Hidalgo; Maartje van de Vorst; Lambertus A Kiemeney; Maria-Mercè Garcia-Barceló; Ivo de Blaauw; Han G Brunner; Nel Roeleveld; Iris A L M van Rooij Journal: PLoS One Date: 2019-05-28 Impact factor: 3.240