Literature DB >> 2556299

A consensus sequence for substrate hydrolysis by rhinovirus 3C proteinase.

A C Long1, D C Orr, J M Cameron, B M Dunn, J Kay.   

Abstract

Kinetic constants were determined for the hydrolysis of a series of synthetic peptide substrates by recombinant rhinovirus (HRV 14) 3C proteinase. Systematic removal or replacement of individual residues indicated that the minimum sequence required for effective cleavage by the viral cysteine proteinase was P5-Val/Thr-P3-P2-Gln-Gly-Pro.

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Year:  1989        PMID： 2556299     DOI： 10.1016/0014-5793(89)81619-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.

Authors:  D A Matthews; P S Dragovich; S E Webber; S A Fuhrman; A K Patick; L S Zalman; T F Hendrickson; R A Love; T J Prins; J T Marakovits; R Zhou; J Tikhe; C E Ford; J W Meador; R A Ferre; E L Brown; S L Binford; M A Brothers; D M DeLisle; S T Worland
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

Review 2.  Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.

Authors:  W G Dougherty; B L Semler
Journal:  Microbiol Rev       Date:  1993-12

3.  Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks.

Authors:  N Blom; J Hansen; D Blaas; S Brunak
Journal:  Protein Sci       Date:  1996-11       Impact factor: 6.725

Review 4.  The picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds.

Authors:  B A Malcolm
Journal:  Protein Sci       Date:  1995-08       Impact factor: 6.725

5.  Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor.

Authors:  J Karow; K R Hudson; M A Hall; A B Vernallis; J A Taylor; A Gossler; J K Heath
Journal:  Biochem J       Date:  1996-09-01       Impact factor: 3.857

6.  3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity.

Authors:  C Wirblich; M Sibilia; M B Boniotti; C Rossi; H J Thiel; G Meyers
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

7.  Analysis of picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions.

Authors:  H H Lu; X Li; A Cuconati; E Wimmer
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103

Review 8.  An overview of enzymatic reagents for the removal of affinity tags.

Authors:  David S Waugh
Journal:  Protein Expr Purif       Date:  2011-08-19       Impact factor: 1.650

9.  Expression and partial purification of recombinant tomato ringspot nepovirus 3C-like proteinase: comparison of the activity of the mature proteinase and the VPg-proteinase precursor.

Authors:  J Chisholm; A Wieczorek; H Sanfaçon
Journal:  Virus Res       Date:  2001-11-05       Impact factor: 3.303

10.  Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.

Authors:  Patricia A Zunszain; Stephen R Knox; Trevor R Sweeney; Jingjie Yang; Núria Roqué-Rosell; Graham J Belsham; Robin J Leatherbarrow; Stephen Curry
Journal:  J Mol Biol       Date:  2009-10-31       Impact factor: 5.469
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