Literature DB >> 2556293

Sequence and expression of a novel GABAA receptor alpha subunit.

S Ymer1, A Draguhn, M Köhler, P R Schofield, P H Seeburg.   

Abstract

Cloned cDNA encoding the bovine alpha 4 subunit of the GABAA receptor has been isolated. The predicted 51 amino acid long mature protein contains an exceptionally long intracellular domain and shares 53-56% sequence similarity to the previously characterized alpha 1, alpha 2 and alpha 3 subunits. Co-expression of alpha 4 and beta 1 in Xenopus oocytes resulted in the formation of GABA-gated chloride channels with expected pharmacology, although no benzodiazepine potentiation was observed. Northern analysis indicates that a 4 kb alpha 4 mRNA is expressed in the calf cerebellum, cortex and hippocampus but is barely detectable in the rat brain.

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Year:  1989        PMID： 2556293     DOI： 10.1016/0014-5793(89)81630-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

Review 1.  Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

Authors:  E Sigel
Journal:  J Membr Biol       Date:  1990-09       Impact factor: 1.843

2.  Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.

Authors:  P Whiting; R M McKernan; L L Iversen
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  Cellular distribution of L-glutamate decarboxylase (GAD) and gamma-aminobutyric acidA (GABAA) receptor mRNAs in the retina.

Authors:  N C Brecha; C Sternini; M F Humphrey
Journal:  Cell Mol Neurobiol       Date:  1991-10       Impact factor: 5.046

4.  The GABAA receptor family in the mammalian brain.

Authors:  R W Olsen; M H Bureau; S Endo; G Smith
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

5.  The genetics of ivermectin resistance in Caenorhabditis elegans.

Authors:  J A Dent; M M Smith; D K Vassilatis; L Avery
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

6.  Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.

Authors:  L Polenzani; R M Woodward; R Miledi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

7.  Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

Authors:  G R Cutting; L Lu; B F O'Hara; L M Kasch; C Montrose-Rafizadeh; D M Donovan; S Shimada; S E Antonarakis; W B Guggino; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

8.  gamma-Aminobutyric acid type A receptor point mutation increases the affinity of compounds for the benzodiazepine site.

Authors:  D B Pritchett; P H Seeburg
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

9.  Nucleus-specific expression of GABA(A) receptor subunit mRNAs in monkey thalamus.

Authors:  M M Huntsman; M G Leggio; E G Jones
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

10.  Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.

Authors:  G Puia; I Ducic; S Vicini; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205
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