Literature DB >> 2556200

Augmentation and subsequent attenuation of Ca2+ current due to lipid peroxidation of the membrane caused by t-butyl hydroperoxide in the rabbit sinoatrial node.

N Sato1, M Nishimura, H Tanaka, N Homma, Y Watanabe.   

Abstract

Cellular electrophysiological effects of membrane lipid peroxidation by t-butyl hydroperoxide (TBH) were studied in the rabbit sinoatrial (SA) node. Superfusion for 1-5 min with 300 microM TBH caused an initial increase and subsequent decrease in the spontaneous firing frequency of the SA node. Voltage clamp experiments revealed that TBH initially enhanced but later blocked the Ca2+ current. Thus, membrane lipid peroxidation appears to accelerate and then suppress physiological automaticity by causing biphasic changes in the Ca2+ current.

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Year:  1989        PMID： 2556200      PMCID： PMC1854779          DOI： 10.1111/j.1476-5381.1989.tb14598.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation.

Authors:  J H Kramer; I T Mak; W B Weglicki
Journal:  Circ Res       Date:  1984-07       Impact factor: 17.367

2.  Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum.

Authors:  M L Hess; E Okabe; H A Kontos
Journal:  J Mol Cell Cardiol       Date:  1981-08       Impact factor: 5.000

3.  The effect of primary products of lipid peroxidation on the transmembrane transport of calcium ions.

Authors:  A V Lebedev; D O Levitsky; V A Loginov; V N Smirnov
Journal:  J Mol Cell Cardiol       Date:  1982-09       Impact factor: 5.000

4.  Calcium-mediated control of Ca and K currents.

Authors:  R Eckert; D L Tillotson; P Brehm
Journal:  Fed Proc       Date:  1981-06

5.  Abnormal electrical activity induced by free radical generating systems in isolated cardiocytes.

Authors:  P L Barrington; C F Meier; W B Weglicki
Journal:  J Mol Cell Cardiol       Date:  1988-12       Impact factor: 5.000

6.  Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium?

Authors:  E Marban; R W Tsien
Journal:  J Physiol       Date:  1982-08       Impact factor: 5.182

7.  Slow inward current and its role mediating the chronotropic effect of epinephrine in the rabbit sinoatrial node.

Authors:  A Noma; H Kotake; H Irisawa
Journal:  Pflugers Arch       Date:  1980-10       Impact factor: 3.657

8.  Electrophysiological derangements induced by lipid peroxidation in cardiac tissue.

Authors:  H Nakaya; N Tohse; M Kanno
Journal:  Am J Physiol       Date:  1987-11

9.  The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart.

Authors:  F Z Meerson; V E Kagan; L M Belkina
Journal:  Basic Res Cardiol       Date:  1982 Sep-Oct       Impact factor: 17.165

Review 10.  Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.

Authors:  M L Hess; N H Manson
Journal:  J Mol Cell Cardiol       Date:  1984-11       Impact factor: 5.000
  10 in total
  3 in total

1.  Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

Authors:  C A Ward; W R Giles
Journal:  J Physiol       Date:  1997-05-01       Impact factor: 5.182

2.  The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea-pig ventricular myocytes.

Authors:  L Guerra; E Cerbai; S Gessi; P A Borea; A Mugelli
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

3.  Effects of membrane lipid peroxidation by tert butyl hydroperoxide on the sodium current in isolated feline ventricular myocytes.

Authors:  T Uchida; M Nishimura; T Saeki; Y Watanabe
Journal:  Heart Vessels       Date:  1994       Impact factor: 2.037
  3 in total

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