Marijana Tadic1, Vera Celic2, Cesare Cuspidi3, Sanja Ilic4, Biljana Pencic5, Jana Radojkovic4, Branislava Ivanovic6, Dejana Stanisavljevic7, Gonenc Kocabay8, Tamara Marjanovic5. 1. Department of Cardiology, University Clinical Hospital Center "Dr Dragisa Misovic - Dedinje," Belgrade, Serbia. Electronic address: marijana_tadic@hotmail.com. 2. Department of Cardiology, University Clinical Hospital Center "Dr Dragisa Misovic - Dedinje," Belgrade, Serbia; Faculty of Medicine, Belgrade, Serbia. 3. Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy. 4. Department of Endocrinology, University Clinical Hospital Center "Dr Dragisa Misovic", Belgrade, Serbia. 5. Department of Cardiology, University Clinical Hospital Center "Dr Dragisa Misovic - Dedinje," Belgrade, Serbia. 6. Faculty of Medicine, Belgrade, Serbia; Clinic of Cardiology, Clinical Center of Serbia, Belgrade, Serbia. 7. Faculty of Medicine, Belgrade, Serbia; Institute for Medical Statistics and Informatics, Belgrade, Serbia. 8. Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Abstract
BACKGROUND: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. METHODS: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. RESULTS: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8 mL/m(2), P < .001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4 vs 22 ± 4 mL/m(2), P < .001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. CONCLUSIONS: RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics.
BACKGROUND: The aim of this study was to determine right ventricular (RV) and right atrial (RA) deformation assessed by two-dimensional echocardiographic and three-dimensional echocardiographic (3DE) imaging in patients with prediabetes and type 2 diabetes mellitus. METHODS: This cross-sectional study included 47 untreated normotensive subjects with prediabetes, 57 recently diagnosed normotensive patients with diabetes, and 54 healthy controls of similar sex and age distributions. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. RESULTS: Three-dimensional echocardiographic RV end-diastolic volume index gradually decreased from controls across patients with diabetes to those with diabetes (69 ± 10 vs 63 ± 8 vs 58 ± 8 mL/m(2), P < .001), whereas 3DE RV end-systolic volume index was higher in controls compared with patients with diabetes and those with diabetes (25 ± 4 vs 23 ± 4 vs 22 ± 4 mL/m(2), P < .001). However, there was no difference in 3DE RV ejection fraction among the three groups (63 ± 4% vs 62 ± 4% vs 61 ± 5%, P = .063). RV and RA global strain and systolic and early diastolic strain rates were decreased in patients with prediabetes and in those with diabetes compared with controls, whereas RV and RA late diastolic strain rates were increased in these patients. Multivariate regression analysis showed that RV global strain was associated with glycated hemoglobin, independent of left ventricular parameters. CONCLUSIONS:RV and RA myocardial deformation and function obtained by 3DE and two-dimensional echocardiographic strain, even in normal ranges, were decreased in patients with prediabetes and in those with diabetes compared with controls. The long-term parameter of glucose control was correlated with the right heart mechanics.
Authors: Marja A Heiskanen; Tanja J Sjöros; Ilkka H A Heinonen; Eliisa Löyttyniemi; Mikko Koivumäki; Kumail K Motiani; Jari-Joonas Eskelinen; Kirsi A Virtanen; Juhani Knuuti; Jarna C Hannukainen; Kari K Kalliokoski Journal: Sci Rep Date: 2017-09-05 Impact factor: 4.379
Authors: Petter Bjornstad; Uyen Truong; Jennifer L Dorosz; Melanie Cree-Green; Amy Baumgartner; Gregory Coe; Laura Pyle; Judith G Regensteiner; Jane E B Reusch; Kristen J Nadeau Journal: J Am Heart Assoc Date: 2016-03-18 Impact factor: 5.501
Authors: Pauline B C Linssen; Marja G J Veugen; Ronald M A Henry; Carla J H van der Kallen; Abraham A Kroon; Miranda T Schram; Hans-Peter Brunner-La Rocca; Coen D A Stehouwer Journal: Cardiovasc Diabetol Date: 2020-06-15 Impact factor: 9.951