Literature DB >> 25560147

Quality control mechanisms in cellular and systemic DNA damage responses.

Maria A Ermolaeva1, Alexander Dakhovnik2, Björn Schumacher3.   

Abstract

The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage is thought to contribute to the functional decline of tissues and organs with ageing. Defects in multiple genome maintenance systems cause human disorders characterized by cancer susceptibility, developmental failure, and premature ageing. The complex pathological consequences of genome instability are insufficiently explained by cell-autonomous DNA damage responses (DDR) alone. Quality control pathways play an important role in DNA repair and cellular DDR pathways. Recent years have revealed non-cell autonomous effects of DNA damage that impact the physiological adaptations during ageing. We will discuss the role of quality assurance pathways in cell-autonomous and systemic responses to genome instability.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Ageing; DNA damage; DNA repair; Genome stability; Progeroid syndromes; Ubiquitin proteasome system

Mesh：

Year:  2015        PMID： 25560147      PMCID： PMC4886828          DOI： 10.1016/j.arr.2014.12.009

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   10.895


  89 in total

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Authors:  Björn Schumacher; Ingrid van der Pluijm; Michael J Moorhouse; Theodore Kosteas; Andria Rasile Robinson; Yousin Suh; Timo M Breit; Harry van Steeg; Laura J Niedernhofer; Wilfred van Ijcken; Andrzej Bartke; Stephen R Spindler; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; George A Garinis
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