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Literature DB >> 25559315

Anticancer agent-based marine natural products and related compounds.

Jian-Wei Chen¹, Qi-Hao Wu, David C Rowley, Ammar M Q Al-Kareef, Hong Wang.

Abstract

Marine natural products constitute a huge reservoir of anticancer agents. Consequently during the past decades, several marine anticancer compounds have been isolated, identified, and approved for anticancer treatment or are under trials. In this article the sources, structure, bioactivities, mode of actions, and analogs of some promising marine and derived anticancer compounds have been discussed.

Keywords: analogs; anticancer drugs; bioactivities; marine natural products; mode of actions

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Year: 2015 PMID： 25559315 DOI： 10.1080/10286020.2014.996140

Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569

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Cited

7 in total

1. Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety.

Authors: Shan Qian; Aashay K Shah; Sarah A Head; Jun O Liu; Zhendong Jin
Journal: Bioorg Med Chem Lett Date: 2016-06-22 Impact factor: 2.823

2. Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice.

Authors: Tse-Hung Huang; Yi-Han Chiu; Yi-Lin Chan; Ya-Huang Chiu; Hang Wang; Kuo-Chin Huang; Tsung-Lin Li; Kuang-Hung Hsu; Chang-Jer Wu
Journal: Mar Drugs Date: 2015-04-03 Impact factor: 5.118

Anticancer agent-based marine natural products and related compounds.

1. Insights into the structure-activity relationship of the anticancer compound ZJ-101, a derivative of marine natural product superstolide A: A critical role played by the conjugated trienyl lactone moiety.

2. Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice.

Review 3. Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

Review 4. Current Screening Methodologies in Drug Discovery for Selected Human Diseases.

Review 5. Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives.

Review 6. Chemistry and Biology of Siderophores from Marine Microbes.

Review 7. The Structural Diversity of Marine Microbial Secondary Metabolites Based on Co-Culture Strategy: 2009-2019.