Literature DB >> 25559195

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

Haruna Takeda1, Zhubo Wei2, Hideto Koso3, Alistair G Rust4, Christopher Chin Kuan Yew5, Michael B Mann6, Jerrold M Ward5, David J Adams4, Neal G Copeland6, Nancy A Jenkins6.   

Abstract

To provide a more comprehensive understanding of the genes and evolutionary forces driving colorectal cancer (CRC) progression, we performed Sleeping Beauty (SB) transposon mutagenesis screens in mice carrying sensitizing mutations in genes that act at different stages of tumor progression. This approach allowed us to identify a set of genes that appear to be highly relevant for CRC and to provide a better understanding of the evolutionary forces and systems properties of CRC. We also identified six genes driving malignant tumor progression and a new human CRC tumor-suppressor gene, ZNF292, that might also function in other types of cancer. Our comprehensive CRC data set provides a resource with which to develop new therapies for treating CRC.

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Year:  2015        PMID： 25559195     DOI： 10.1038/ng.3175

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  56 in total

1.  Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression.

Authors:  Roberto Rangel; Song-Choon Lee; Kenneth Hon-Kim Ban; Liliana Guzman-Rojas; Michael B Mann; Justin Y Newberg; Takahiro Kodama; Leslie A McNoe; Luxmanan Selvanesan; Jerrold M Ward; Alistair G Rust; Kuan-Yew Chin; Michael A Black; Nancy A Jenkins; Neal G Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2016-11-14       Impact factor: 11.205

2.  SB Driver Analysis: a Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors.

Authors:  Justin Y Newberg; Michael A Black; Nancy A Jenkins; Neal G Copeland; Karen M Mann; Michael B Mann
Journal:  Nucleic Acids Res       Date:  2018-09-19       Impact factor: 16.971

3.  CFTR is a tumor suppressor gene in murine and human intestinal cancer.

Authors:  B L N Than; J F Linnekamp; T K Starr; D A Largaespada; A Rod; Y Zhang; V Bruner; J Abrahante; A Schumann; T Luczak; A Niemczyk; M G O'Sullivan; J P Medema; R J A Fijneman; G A Meijer; E Van den Broek; C A Hodges; P M Scott; L Vermeulen; R T Cormier
Journal:  Oncogene       Date:  2016-01-11       Impact factor: 9.867

4.  Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma.

Authors:  Takahiro Kodama; Justin Y Newberg; Michiko Kodama; Roberto Rangel; Kosuke Yoshihara; Jean C Tien; Pamela H Parsons; Hao Wu; Milton J Finegold; Neal G Copeland; Nancy A Jenkins
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-31       Impact factor: 11.205

Review 5.  In vivo functional screening for systems-level integrative cancer genomics.

Authors:  Julia Weber; Christian J Braun; Dieter Saur; Roland Rad
Journal:  Nat Rev Cancer       Date:  2020-07-07       Impact factor: 60.716

6.  MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM.

Authors:  Takahiro Kodama; Teresa A Marian; Hubert Lee; Michiko Kodama; Jian Li; Michael S Parmacek; Nancy A Jenkins; Neal G Copeland; Zhubo Wei
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-05       Impact factor: 11.205

7.  Reply to Zhao et al.: NOMO1 is a potential target gene of MRTFB.

Authors:  Teresa A Marian; Zhubo Wei
Journal:  Proc Natl Acad Sci U S A       Date:  2020-03-17       Impact factor: 11.205

8.  Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq.

Authors:  Karen M Mann; Justin Y Newberg; Michael A Black; Devin J Jones; Felipe Amaya-Manzanares; Liliana Guzman-Rojas; Takahiro Kodama; Jerrold M Ward; Alistair G Rust; Louise van der Weyden; Christopher Chin Kuan Yew; Jill L Waters; Marco L Leung; Keith Rogers; Susan M Rogers; Leslie A McNoe; Luxmanan Selvanesan; Nicholas Navin; Nancy A Jenkins; Neal G Copeland; Michael B Mann
Journal:  Nat Biotechnol       Date:  2016-08-01       Impact factor: 54.908

9.  Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types.

Authors:  Yanan Cao; Weiwei Zhou; Lin Li; Jiaqian Wang; Zhibo Gao; Yiran Jiang; Xiuli Jiang; Aijing Shan; Matthew H Bailey; Kuan-Lin Huang; Sam Q Sun; Michael D McLellan; Beifang Niu; Weiqing Wang; Li Ding; Guang Ning
Journal:  Cell Res       Date:  2018-03-05       Impact factor: 25.617

Review 10.  The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters.

Authors:  Arnold J Levine; Nancy A Jenkins; Neal G Copeland
Journal:  Cancer Cell       Date:  2019-01-14       Impact factor: 31.743
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