Literature DB >> 25558270

From a Cell's Viewpoint: Targeting Mitochondria in Alzheimer's disease.

Emily Ann Carlson1, Valasani Koteswara Rao1, Shirley ShiDu Yan1.   

Abstract

Mitochondria are well-known cellular organelles widely studied in relation to a variety of disease states, including Alzheimer's disease. With roles in several metabolic processes, numerous signal transduction pathways, and overall cell maintenance and survival, mitochondria are essential to understanding the inner workings of cells. As mitochondria are able to be utilized by diverse illnesses to increase the likelihood of disease progression, targeting specific processes in these organelles could provide beneficial therapeutic options.

Entities:  

Year:  2013        PMID： 25558270      PMCID： PMC4280837          DOI： 10.1016/j.ddstr.2014.04.002

Source DB:  PubMed          Journal:  Drug Discov Today Ther Strateg        ISSN： 1740-6773


  37 in total

1.  Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

Authors:  Matthew G Bartley; Kristin Marquardt; Danielle Kirchhof; Heather M Wilkins; David Patterson; Daniel A Linseman
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

2.  Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.

Authors:  Michael Gold; Claire Alderton; Marina Zvartau-Hind; Sally Egginton; Ann M Saunders; Michael Irizarry; Suzanne Craft; Gary Landreth; Ulla Linnamägi; Sharon Sawchak
Journal:  Dement Geriatr Cogn Disord       Date:  2010-08-21       Impact factor: 2.959

3.  Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD.

Authors:  Rainer Hellweg; Yvonne Wirth; Wolfgang Janetzky; Susanne Hartmann
Journal:  Int J Geriatr Psychiatry       Date:  2011-08-25       Impact factor: 3.485

4.  Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

Authors:  Jun Yao; Heng Du; Shiqiang Yan; Fang Fang; Chaodong Wang; Lih-Fen Lue; Lan Guo; Doris Chen; David M Stern; Frank J Gunn Moore; John Xi Chen; Ottavio Arancio; Shirley ShiDu Yan
Journal:  J Neurosci       Date:  2011-02-09       Impact factor: 6.167

5.  Possible role of amyloid-beta, adenine nucleotide translocase and cyclophilin-D interaction in mitochondrial dysfunction of Alzheimer's disease.

Authors:  Prabhakar Singh; Shubhankar Suman; Sudhir Chandna; Taposh Kumar Das
Journal:  Bioinformation       Date:  2009-08-04

6.  Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

Authors:  Dong-Gyu Jo; Thiruma V Arumugam; Ha-Na Woo; Jong-Sung Park; Sung-Chun Tang; Mohamed Mughal; Dong-Hoon Hyun; Jun-Hyung Park; Yun-Hyung Choi; A-Ryeong Gwon; Simonetta Camandola; Aiwu Cheng; Huaibin Cai; Weihong Song; William R Markesbery; Mark P Mattson
Journal:  Neurobiol Aging       Date:  2008-08-08       Impact factor: 4.673

7.  Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.

Authors:  Virginie Rhein; Xiaomin Song; Andreas Wiesner; Lars M Ittner; Ginette Baysang; Fides Meier; Laurence Ozmen; Horst Bluethmann; Stefan Dröse; Ulrich Brandt; Egemen Savaskan; Christian Czech; Jürgen Götz; Anne Eckert
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-06       Impact factor: 11.205

8.  Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model.

Authors:  Heng Du; Lan Guo; Wensheng Zhang; Monika Rydzewska; Shidu Yan
Journal:  Neurobiol Aging       Date:  2009-04-11       Impact factor: 4.673

9.  Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.

Authors:  Laura E Jensen; Geert Bultynck; Tomas Luyten; Hozeefa Amijee; Martin D Bootman; H Llewelyn Roderick
Journal:  Front Mol Neurosci       Date:  2013-11-05       Impact factor: 5.639

10.  Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.

Authors:  Christopher P Baines; Robert A Kaiser; Tatiana Sheiko; William J Craigen; Jeffery D Molkentin
Journal:  Nat Cell Biol       Date:  2007-04-08       Impact factor: 28.824
View more
  1 in total

Review 1.  Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies.

Authors:  Yuting Cui; Mingyue Pan; Jing Ma; Xinhua Song; Weiling Cao; Peng Zhang
Journal:  Mol Cell Biochem       Date:  2020-09-30       Impact factor: 3.396
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.