BACKGROUND: To develop and validate a method for quantifying myocardial blood flow (MBF) using dynamic perfusion magnetic resonance imaging (MBFMRI ) at 3.0 Tesla (T) and compare the findings with those of (15) O-water positron emission tomography (MBFPET ). METHODS: Twenty healthy male volunteers underwent magnetic resonance imaging (MRI) and (15) O-water positron emission tomography (PET) at rest and during adenosine triphosphate infusion. The single-tissue compartment model was used to estimate the inflow rate constant (K1). We estimated the extraction fraction of Gd-DTPA using K1 and MBF values obtained from (15) O-water PET for the first 10 subjects. For validation, we calculated MBFMRI values for the remaining 10 subjects and compared them with the MBFPET values. In addition, we compared MBFMRI values of 10 patients with coronary artery disease with those of healthy subjects. RESULTS: The mean resting and stress MBFMRI values were 0.76 ± 0.10 and 3.04 ± 0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBFPET values (r = 0.96, P < 0.01). The mean stress MBFMRI value was significantly lower for the patients (1.92 ± 0.37) than for the healthy subjects (P < 0.001). CONCLUSION: The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease.
BACKGROUND: To develop and validate a method for quantifying myocardial blood flow (MBF) using dynamic perfusion magnetic resonance imaging (MBFMRI ) at 3.0 Tesla (T) and compare the findings with those of (15) O-water positron emission tomography (MBFPET ). METHODS: Twenty healthy male volunteers underwent magnetic resonance imaging (MRI) and (15) O-water positron emission tomography (PET) at rest and during adenosine triphosphate infusion. The single-tissue compartment model was used to estimate the inflow rate constant (K1). We estimated the extraction fraction of Gd-DTPA using K1 and MBF values obtained from (15) O-water PET for the first 10 subjects. For validation, we calculated MBFMRI values for the remaining 10 subjects and compared them with the MBFPET values. In addition, we compared MBFMRI values of 10 patients with coronary artery disease with those of healthy subjects. RESULTS: The mean resting and stress MBFMRI values were 0.76 ± 0.10 and 3.04 ± 0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBFPET values (r = 0.96, P < 0.01). The mean stress MBFMRI value was significantly lower for the patients (1.92 ± 0.37) than for the healthy subjects (P < 0.001). CONCLUSION: The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease.
Authors: Sethumadhavan Vijayan; David S Barmby; Ian R Pearson; Andrew G Davies; Stephen B Wheatcroft; Mohan Sivananthan Journal: Curr Cardiol Rev Date: 2017
Authors: G Papanastasiou; M C Williams; M R Dweck; S Mirsadraee; N Weir; A Fletcher; C Lucatelli; D Patel; E J R van Beek; D E Newby; S I K Semple Journal: IEEE Trans Radiat Plasma Med Sci Date: 2018-01-23
Authors: Henk Everaars; Pepijn A van Diemen; Michiel J Bom; Stefan P Schumacher; Ruben W de Winter; Peter M van de Ven; Pieter G Raijmakers; Adriaan A Lammertsma; Mark B M Hofman; Rob J van der Geest; Marco J Götte; Albert C van Rossum; Robin Nijveldt; Ibrahim Danad; Roel S Driessen; Paul Knaapen Journal: Eur J Nucl Med Mol Imaging Date: 2019-12-10 Impact factor: 9.236
Authors: Håkan Ahlström; Mark Lubberink; Tanja Kero; Edvin Johansson; Mathias Engström; Kai M Eggers; Lars Johansson Journal: J Nucl Cardiol Date: 2019-07-16 Impact factor: 5.952