Literature DB >> 25556851

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89.

Darpan N Pandya1, Sylvie Pailloux, David Tatum, Darren Magda, Thaddeus J Wadas.   

Abstract

The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 ((89)Zr) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with (89)Zr and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for (89)Zr.

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Year:  2015        PMID： 25556851      PMCID： PMC4507282          DOI： 10.1039/c4cc09256b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  22 in total

1.  Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units.

Authors:  Rebecca J Abergel; Kenneth N Raymond
Journal:  Inorg Chem       Date:  2006-05-01       Impact factor: 5.165

2.  ⁸⁹Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer.

Authors:  Neeta Pandit-Taskar; Joseph A O'Donoghue; Volkan Beylergil; Serge Lyashchenko; Shutian Ruan; Stephen B Solomon; Jeremy C Durack; Jorge A Carrasquillo; Robert A Lefkowitz; Mithat Gonen; Jason S Lewis; Jason P Holland; Sarah M Cheal; Victor E Reuter; Joseph R Osborne; Massimo F Loda; Peter M Smith-Jones; Wolfgang A Weber; Neil H Bander; Howard I Scher; Michael J Morris; Steven M Larson
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-08-21       Impact factor: 9.236

3.  Targeting the internal epitope of prostate-specific membrane antigen with 89Zr-7E11 immuno-PET.

Authors:  Alessandro Ruggiero; Jason P Holland; Tvrtko Hudolin; Larissa Shenker; Anna Koulova; Neil H Bander; Jason S Lewis; Jan Grimm
Journal:  J Nucl Med       Date:  2011-09-09       Impact factor: 10.057

4.  89Zr-DFO-J591 for immunoPET of prostate-specific membrane antigen expression in vivo.

Authors:  Jason P Holland; Vadim Divilov; Neil H Bander; Peter M Smith-Jones; Steven M Larson; Jason S Lewis
Journal:  J Nucl Med       Date:  2010-07-21       Impact factor: 10.057

5.  Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.

Authors:  François Guérard; Yong-Sok Lee; Raphaël Tripier; Lawrence P Szajek; Jeffrey R Deschamps; Martin W Brechbiel
Journal:  Chem Commun (Camb)       Date:  2012-12-19       Impact factor: 6.222

6.  Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.

Authors:  Jason P Holland; Eloisi Caldas-Lopes; Vadim Divilov; Valerie A Longo; Tony Taldone; Danuta Zatorska; Gabriela Chiosis; Jason S Lewis
Journal:  PLoS One       Date:  2010-01-25       Impact factor: 3.240

7.  A bidentate terephthalamide ligand, TAMmeg, as an entry into terephthalamide-containing therapeutic iron chelating agents.

Authors:  Kristy M Clarke Jurchen; Kenneth N Raymond
Journal:  Inorg Chem       Date:  2006-03-20       Impact factor: 5.165

8.  Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

Authors:  Yelena Y Janjigian; Nerissa Viola-Villegas; Jason P Holland; Vadim Divilov; Sean D Carlin; Erica M Gomes-DaGama; Gabriela Chiosis; Gregory Carbonetti; Elisa de Stanchina; Jason S Lewis
Journal:  J Nucl Med       Date:  2013-04-11       Impact factor: 10.057

9.  Annotating MYC status with 89Zr-transferrin imaging.

Authors:  Jason P Holland; Michael J Evans; Samuel L Rice; John Wongvipat; Charles L Sawyers; Jason S Lewis
Journal:  Nat Med       Date:  2012-09-23       Impact factor: 53.440

10.  Alternative chelator for ⁸⁹Zr radiopharmaceuticals: radiolabeling and evaluation of 3,4,3-(LI-1,2-HOPO).

Authors:  Melissa A Deri; Shashikanth Ponnala; Brian M Zeglis; Gabor Pohl; J J Dannenberg; Jason S Lewis; Lynn C Francesconi
Journal:  J Med Chem       Date:  2014-05-19       Impact factor: 7.446
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  17 in total

1.  Macrocycle-Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging.

Authors:  Eszter Boros; Jason P Holland; Nathaniel Kenton; Nicholas Rotile; Peter Caravan
Journal:  Chempluschem       Date:  2016-01-25       Impact factor: 2.863

2.  Investigation of the complexation of natZr(iv) and 89Zr(iv) by hydroxypyridinones for the development of chelators for PET imaging applications.

Authors:  F Guérard; M Beyler; Y-S Lee; R Tripier; J-F Gestin; M W Brechbiel
Journal:  Dalton Trans       Date:  2017-04-05       Impact factor: 4.390

3.  Polyazamacrocycle Ligands Facilitate 89Zr Radiochemistry and Yield 89Zr Complexes with Remarkable Stability.

Authors:  Darpan N Pandya; Kelly E Henry; Cynthia S Day; Stephen A Graves; Veronica L Nagle; Thomas R Dilling; Akesh Sinha; Brandie M Ehrmann; Nikunj B Bhatt; Yusuf Menda; Jason S Lewis; Thaddeus J Wadas
Journal:  Inorg Chem       Date:  2020-11-10       Impact factor: 5.165

4.  A comprehensively revised strategy that improves the specific activity and long-term stability of clinically relevant 89Zr-immuno-PET agents.

Authors:  Nikunj B Bhatt; Darpan N Pandya; Stephanie Rideout-Danner; Howard D Gage; Frank C Marini; Thaddeus J Wadas
Journal:  Dalton Trans       Date:  2018-09-04       Impact factor: 4.390

5.  Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.

Authors:  L Allott; C Da Pieve; J Meyers; T Spinks; D M Ciobota; G Kramer-Marek; G Smith
Journal:  Chem Commun (Camb)       Date:  2017-07-27       Impact factor: 6.222

6.  Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin.

Authors:  Stephen A Graves; Christopher Kutyreff; Kendall E Barrett; Reinier Hernandez; Paul A Ellison; Steffen Happel; Eduardo Aluicio-Sarduy; Todd E Barnhart; Robert J Nickles; Jonathan W Engle
Journal:  Nucl Med Biol       Date:  2018-06-18       Impact factor: 2.408

7.  A High-Denticity Chelator Based on Desferrioxamine for Enhanced Coordination of Zirconium-89.

Authors:  Elaheh Khozeimeh Sarbisheh; Akam K Salih; Shvan J Raheem; Jason S Lewis; Eric W Price
Journal:  Inorg Chem       Date:  2020-07-28       Impact factor: 5.165

8.  p-SCN-Bn-HOPO: A Superior Bifunctional Chelator for (89)Zr ImmunoPET.

Authors:  Melissa A Deri; Shashikanth Ponnala; Paul Kozlowski; Benjamin P Burton-Pye; Huseyin T Cicek; Chunhua Hu; Jason S Lewis; Lynn C Francesconi
Journal:  Bioconjug Chem       Date:  2015-11-25       Impact factor: 4.774

9.  Novel Bifunctional Cyclic Chelator for (89)Zr Labeling-Radiolabeling and Targeting Properties of RGD Conjugates.

Authors:  Chuangyan Zhai; Dominik Summer; Christine Rangger; Gerben M Franssen; Peter Laverman; Hubertus Haas; Milos Petrik; Roland Haubner; Clemens Decristoforo
Journal:  Mol Pharm       Date:  2015-05-19       Impact factor: 4.939

10.  Preliminary Therapy Evaluation of (225)Ac-DOTA-c(RGDyK) Demonstrates that Cerenkov Radiation Derived from (225)Ac Daughter Decay Can Be Detected by Optical Imaging for In Vivo Tumor Visualization.

Authors:  Darpan N Pandya; Roy Hantgan; Mikalai M Budzevich; Nancy D Kock; David L Morse; Izadora Batista; Akiva Mintz; King C Li; Thaddeus J Wadas
Journal:  Theranostics       Date:  2016-03-01       Impact factor: 11.556
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