BACKGROUND: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancer patients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. MATERIALS AND METHODS: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). RESULTS: NLR values were significantly higher in the PBC patients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBC patients. CONCLUSIONS: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.
BACKGROUND: The aim of this study was to determine diagnostic and prognostic roles of the neutrophil to lymphocyte ratio (NLR) in breast cancerpatients. To date, data are limited on associations of primary breast carcinoma (PBC) and benign proliferative breast disease (BPBD) with preoperative NLR values. MATERIALS AND METHODS: Our study covered of 120 female patients with PBC and 50 with BPBD. Diagnostic values of NLR were estimated using sensitivity, specificity and areas under receiver operating characteristic curves (AUC). RESULTS: NLR values were significantly higher in the PBCpatients than in those with BPBD, with an AUC of 0.668 in the PBC case. The optimal cut-off for NLR was 2.96 and this was validated in the testing set, giving a sensitivity and a specificity of 79.7% and 76.2%, respectively, in PBCpatients. CONCLUSIONS: Preoperative high NLR is a significant diagnostic predictor of distinction of breast cancer from BPBD and elevated NLR is also an important prognostic marker for primary invasive breast cancer.
Authors: Hyunjung Kim; Hae Il Jung; Soon Ha Kwon; Sang Ho Bae; Hyung Chul Kim; Moo-Jun Baek; Moon Soo Lee Journal: Ann Surg Treat Res Date: 2019-03-28 Impact factor: 1.859
Authors: Mauricio Rivas; Francisco Acevedo; Francisco Dominguez; Hector Galindo; Mauricio Camus; David Oddo; Alejandra Villarroel; Dravna Razmilic; Jose Peña; Matias Munoz Medel; Maria Elena Navarro; Alejandra Perez-Sepulveda; Lidia Medina; Tomas Merino; Juan Briones; Alexis Kalergis; Cesar Sanchez Journal: Asian Pac J Cancer Prev Date: 2019-07-01