Literature DB >> 2555568

Constitutive expression of simian virus 40 large T antigen in monkey cells activates their capacity to support polyomavirus replication.

W J Tang1, W R Folk.   

Abstract

Polyomavirus DNA replication is normally restricted to rodent cells, and simian virus 40 (SV40) DNA replication is restricted to primate cells. We demonstrate that DNAs containing the polyomavirus origin can be replicated in monkey cells which constitutively express SV40 large T antigen. Permissivity is most likely caused by SV40 T antigen modification of cellular protein(s) required to replicate the polyomavirus origin. A possible target for the T-antigen-induced modification is DNA polymerase alpha-DNA primase.

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Year:  1989        PMID： 2555568      PMCID： PMC251220          DOI： 10.1128/JVI.63.12.5478-5482.1989

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  47 in total

1.  T antigen is bound to a host protein in SV40-transformed cells.

Authors:  D P Lane; L V Crawford
Journal:  Nature       Date:  1979-03-15       Impact factor: 49.962

2.  Enzymatic activities associated with a purified simian virus 40 T antigen-related protein.

Authors:  R Tjian; A Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  T antigen repression of SV40 early transcription from two promoters.

Authors:  U Hansen; D G Tenen; D M Livingston; P A Sharp
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

4.  Assay of transforming activity of tumor virus DNA.

Authors:  A J van der Eb; F L Graham
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

5.  Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA.

Authors:  B A Parker; G R Stark
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

6.  Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

Authors:  D I Linzer; A J Levine
Journal:  Cell       Date:  1979-05       Impact factor: 41.582

7.  Essential nucleotides in the polyomavirus origin region.

Authors:  S J Triezenberg; W R Folk
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103

8.  Isolation of mutants of an animal virus in bacteria.

Authors:  K W Peden; J M Pipas; S Pearson-White; D Nathans
Journal:  Science       Date:  1980-09-19       Impact factor: 47.728

9.  Simian virus 40 T antigen binds to DNA.

Authors:  R B Carroll; L Hager; R Dulbecco
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

10.  Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen.

Authors:  J Brady; J B Bolen; M Radonovich; N Salzman; G Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205
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  5 in total

1.  AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.

Authors:  W Guo; W J Tang; X Bu; V Bermudez; M Martin; W R Folk
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

2.  Intrachromosomal recombination mediated by papovavirus large T antigens.

Authors:  L St-Onge; L Bouchard; S Laurent; M Bastin
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

3.  Polyomavirus DNA replication in the pancreas and in a transformed pancreas cell line has distinct enhancer requirements.

Authors:  R Rochford; L P Villarreal
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

4.  Novel Human Polyomavirus Noncoding Control Regions Differ in Bidirectional Gene Expression according to Host Cell, Large T-Antigen Expression, and Clinically Occurring Rearrangements.

Authors:  Elvis T Ajuh; Zongsong Wu; Emma Kraus; Fabian H Weissbach; Tobias Bethge; Rainer Gosert; Nicole Fischer; Hans H Hirsch
Journal:  J Virol       Date:  2018-03-14       Impact factor: 5.103

5.  Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.

Authors:  L Li; B L Li; M Hock; E Wang; W R Folk
Journal:  J Virol       Date:  1995-12       Impact factor: 5.103
  5 in total

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