Literature DB >> 2555555

High-frequency leader sequence switching during coronavirus defective interfering RNA replication.

S Makino1, M M Lai.   

Abstract

A system was developed that exploited defective interfering (DI) RNAs of coronavirus to study the role of free leader RNA in RNA replication. A cDNA copy of mouse hepatitis virus DI RNA was placed downstream of the T7 RNA polymerase promoter to generate DI RNAs capable of extremely efficient replication in the presence of a helper virus. We demonstrated that, in the DI RNA-transfected cells, the leader sequence of these DI RNAs was switched to that of the helper virus during one round of replication. This high-frequency leader sequence exchange was not observed if a nine-nucleotide stretch of sequence (UUUAUAAAC) at the junction between the leader and the remaining DI sequence was deleted. This observation suggests that a free leader RNA generated from the genomic RNA of mouse hepatitis virus may participate in the replication of DI RNA.

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Year:  1989        PMID： 2555555      PMCID： PMC251194          DOI： 10.1128/JVI.63.12.5285-5292.1989

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

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Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

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Journal:  Arch Gesamte Virusforsch       Date:  1974

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Authors:  F S Pedersen; W A Haseltine
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

4.  Extraction of nucleic acids from agarose gels.

Authors:  J Langridge; P Langridge; P L Bergquist
Journal:  Anal Biochem       Date:  1980-04       Impact factor: 3.365

5.  3'-terminal nucleotide sequence of encephalomyocarditis virus RNA determined by reverse transcriptase and chain-terminating inhibitors.

Authors:  D Zimmern; P Kaesberg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

6.  Replication of mouse hepatitis virus: negative-stranded RNA and replicative form RNA are of genome length.

Authors:  M M Lai; C D Patton; S A Stohlman
Journal:  J Virol       Date:  1982-11       Impact factor: 5.103

7.  Mouse hepatitis virus A59: mRNA structure and genetic localization of the sequence divergence from hepatotropic strain MHV-3.

Authors:  M M Lai; P R Brayton; R C Armen; C D Patton; C Pugh; S A Stohlman
Journal:  J Virol       Date:  1981-09       Impact factor: 5.103

8.  A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription.

Authors:  S J Plotch; M Bouloy; I Ulmanen; R M Krug
Journal:  Cell       Date:  1981-03       Impact factor: 41.582

9.  Evolution of the 5'-end of genomic RNA of murine coronaviruses during passages in vitro.

Authors:  S Makino; M M Lai
Journal:  Virology       Date:  1989-03       Impact factor: 3.616

10.  The virus-specific intracellular RNA species of two murine coronaviruses: MHV-a59 and MHV-JHM.

Authors:  J L Leibowitz; K C Wilhelmsen; C W Bond
Journal:  Virology       Date:  1981-10-15       Impact factor: 3.616
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  56 in total

1.  Downstream sequences influence the choice between a naturally occurring noncanonical and closely positioned upstream canonical heptameric fusion motif during bovine coronavirus subgenomic mRNA synthesis.

Authors:  A Ozdarendeli; S Ku; S Rochat; G D Williams; S D Senanayake; D A Brian
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

2.  The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.

Authors:  R J de Groot; R G van der Most; W J Spaan
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

3.  5'-proximal hot spot for an inducible positive-to-negative-strand template switch by coronavirus RNA-dependent RNA polymerase.

Authors:  Hung-Yi Wu; David A Brian
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

4.  Replication of murine coronavirus defective interfering RNA from negative-strand transcripts.

Authors:  M Joo; S Banerjee; S Makino
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

5.  The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA.

Authors:  R Y Chang; R Krishnan; D A Brian
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

6.  A cis-acting function for the coronavirus leader in defective interfering RNA replication.

Authors:  R Y Chang; M A Hofmann; P B Sethna; D A Brian
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

7.  Coronavirus leader RNA regulates and initiates subgenomic mRNA transcription both in trans and in cis.

Authors:  X Zhang; C L Liao; M M Lai
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

8.  Requirement of the 5'-end genomic sequence as an upstream cis-acting element for coronavirus subgenomic mRNA transcription.

Authors:  C L Liao; M M Lai
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

9.  An RNA stem-loop within the bovine coronavirus nsp1 coding region is a cis-acting element in defective interfering RNA replication.

Authors:  Cary G Brown; Kimberley S Nixon; Savithra D Senanayake; David A Brian
Journal:  J Virol       Date:  2007-05-02       Impact factor: 5.103

10.  Genetics of mouse hepatitis virus transcription: evidence that subgenomic negative strands are functional templates.

Authors:  M C Schaad; R S Baric
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103
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