| Literature DB >> 25555480 |
Minoru Kojima1, Naoya Nakamura, Miharu Yabe, Mami Tokunaka, Yara Yukie Kikuti, Tomoki Kikuchi, Hiromichi Murayama, Makiko Moriuchi, Kosuke Tsuboi, Yoshiaki Ogawa, Kiyoshi Ando.
Abstract
We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct. The patient received the R-Hyper CVAD/R-MA regimen; however, leukoencephalopathy subsequently developed due to the effect of cytarabine, and the regimen was changed to R-IVAM. The patient achieved complete remission and received high-dose chemotherapy following autologous stem cell transplantation. He maintained the complete remission for 72 months after transplantation. Given this outcome, we suggest that clonally distinct relapse of HIV-negative BL may exhibit a good prognosis.Entities:
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Year: 2015 PMID： 25555480 DOI： 10.1007/s12185-014-1729-1
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490