Literature DB >> 25554682

Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.

Gustavo A Barisone1, Noriko Satake2, Carly Lewis3, Connie Duong3, Cathy Chen3, Kit S Lam4, Jan Nolta5, Elva Dίaz6.   

Abstract

MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; MXD3; Precursor B acute lymphoblastic leukemia; Proliferation

Mesh：

Substances：

Year:  2014        PMID： 25554682      PMCID： PMC4387021          DOI： 10.1016/j.bcmd.2014.12.002

Source DB:  PubMed          Journal:  Blood Cells Mol Dis        ISSN： 1079-9796            Impact factor:   3.039


  19 in total

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Authors:  C Grandori; S M Cowley; L P James; R N Eisenman
Journal:  Annu Rev Cell Dev Biol       Date:  2000       Impact factor: 13.827

2.  S-phase-specific expression of the Mad3 gene in proliferating and differentiating cells.

Authors:  E J Fox; S C Wright
Journal:  Biochem J       Date:  2001-10-15       Impact factor: 3.857

3.  Molecular analysis of gene expression in the developing pontocerebellar projection system.

Authors:  Elva Díaz; Yongchao Ge; Yee Hwa Yang; Kenneth C Loh; Tito A Serafini; Yasushi Okazaki; Yoshihide Hayashizaki; Terence P Speed; John Ngai; Peter Scheiffele
Journal:  Neuron       Date:  2002-10-24       Impact factor: 17.173

4.  Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis.

Authors:  C Quéva; G A McArthur; B M Iritani; R N Eisenman
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272

Review 5.  Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

Authors:  Ching-Hon Pui; Charles G Mullighan; William E Evans; Mary V Relling
Journal:  Blood       Date:  2012-06-22       Impact factor: 22.113

6.  A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

Authors:  D E Ayer; R N Eisenman
Journal:  Genes Dev       Date:  1993-11       Impact factor: 11.361

7.  Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.

Authors:  D E Ayer; L Kretzner; R N Eisenman
Journal:  Cell       Date:  1993-01-29       Impact factor: 41.582

Review 8.  Late effects among survivors of leukemia during childhood and adolescence.

Authors:  Smita Bhatia
Journal:  Blood Cells Mol Dis       Date:  2003 Jul-Aug       Impact factor: 3.039

9.  Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.

Authors:  D E Ayer; Q A Lawrence; R N Eisenman
Journal:  Cell       Date:  1995-03-10       Impact factor: 41.582

10.  Role of MXD3 in proliferation of DAOY human medulloblastoma cells.

Authors:  Gustavo A Barisone; Tin Ngo; Martin Tran; Daniel Cortes; Mehdi H Shahi; Tuong-Vi Nguyen; Daniel Perez-Lanza; Wanna Matayasuwan; Elva Díaz
Journal:  PLoS One       Date:  2012-07-10       Impact factor: 3.240
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  12 in total

Review 1.  Advances in biology of acute lymphoblastic leukemia (ALL) and therapeutic implications.

Authors:  Mahsa Mohseni; Hasan Uludag; Joseph M Brandwein
Journal:  Am J Blood Res       Date:  2018-12-10

Review 2.  Normal and Neoplastic Growth Suppression by the Extended Myc Network.

Authors:  Edward V Prochownik; Huabo Wang
Journal:  Cells       Date:  2022-02-21       Impact factor: 6.600

3.  Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate.

Authors:  Noriko Satake; Connie Duong; Sakiko Yoshida; Michael Oestergaard; Cathy Chen; Rachael Peralta; Shuling Guo; Punit P Seth; Yueju Li; Laurel Beckett; Jong Chung; Jan Nolta; Nitin Nitin; Joseph M Tuscano
Journal:  Mol Med       Date:  2016-07-22       Impact factor: 6.354

4.  MXD3 antisense oligonucleotide with superparamagnetic iron oxide nanoparticles: A new targeted approach for neuroblastoma.

Authors:  Sakiko Yoshida; Connie Duong; Michael Oestergaard; Michael Fazio; Cathy Chen; Rachael Peralta; Shuling Guo; Punit P Seth; Yueju Li; Laurel Beckett; Nitin Nitin; Noriko Satake
Journal:  Nanomedicine       Date:  2019-11-26       Impact factor: 5.307

5.  Novel targeted therapy for neuroblastoma: silencing the MXD3 gene using siRNA.

Authors:  Connie Duong; Sakiko Yoshida; Cathy Chen; Gustavo Barisone; Elva Diaz; Yueju Li; Laurel Beckett; Jong Chung; Reuben Antony; Jan Nolta; Nitin Nitin; Noriko Satake
Journal:  Pediatr Res       Date:  2017-05-31       Impact factor: 3.756

6.  20(S)-Ginsenoside Rh2 Induce the Apoptosis and Autophagy in U937 and K562 Cells.

Authors:  Jianjian Zhuang; Juxin Yin; Chaojian Xu; Ying Mu; Shaowu Lv
Journal:  Nutrients       Date:  2018-03-08       Impact factor: 5.717

7.  Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma.

Authors:  Tin Ngo; Abraham Corrales; Traci Bourne; Samir Elmojahid; Kit S Lam; Elva Díaz
Journal:  Front Mol Biosci       Date:  2019-02-19

8.  Overexpression of MAX dimerization protein 3 (MXD3) predicts poor prognosis in clear cell renal cell carcinoma.

Authors:  Fangyuan Zhang; Liansheng Liu; Pengjie Wu; Shengwen Li; Dong Wei
Journal:  Transl Androl Urol       Date:  2021-02

9.  Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells.

Authors:  Ting Xia; Jiancheng Wang; Yingnan Wang; Yuanyuan Wang; Jianye Cai; Min Wang; Qidan Chen; Jia Song; Ziqi Yu; Wei Huang; Jianpei Fang
Journal:  Oncotarget       Date:  2016-05-10

10.  MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis.

Authors:  Yi-Wen Tsai; Kuo-Shyang Jeng; Mu-Kuang He; Yang-Wen Hsieh; Hsin-Hung Lai; Chi-Yu Lai; Chun-Chieh Huang; Chiung-Fang Chang; Chung-Tsui Huang; Guor Mour Her
Journal:  Cells       Date:  2021-12-06       Impact factor: 6.600
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