Literature DB >> 2555449

A molecular modelling study of the interaction of noradrenaline with the beta 2-adrenergic receptor.

T J Mitchell1, M S Tute, G A Webb.   

Abstract

A model of the beta 2-adrenergic receptor binding site is built from the primary structure of the receptor, experimental evidence for key binding residues and analogy with a homologous protein of partially determined structure. It is suggested that residues Trp-109, Thr-110 and Asp-113 are involved in ligand binding. Noradrenaline is successfully docked into this model, and the results of an INDO molecular orbital calculation on the complex indicate that a charge transfer interaction between Trp-109 and noradrenaline is possible.

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Year:  1989        PMID： 2555449     DOI： 10.1007/BF01533069

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN： 0920-654X            Impact factor:   3.686


  41 in total

1.  Cloning of the cDNA for the human beta 1-adrenergic receptor.

Authors:  T Frielle; S Collins; K W Daniel; M G Caron; R J Lefkowitz; B K Kobilka
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

2.  Molecular orbital studies on the mechanism of drug-receptor interaction. 2. beta-Adrenergic drugs. An approach to explain the role of the aromatic moiety.

Authors:  C Petrongolo; B Macchia; F Macchia; A Martinelli
Journal:  J Med Chem       Date:  1977-12       Impact factor: 7.446

3.  Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.

Authors:  R A Dixon; B K Kobilka; D J Strader; J L Benovic; H G Dohlman; T Frielle; M A Bolanowski; C D Bennett; E Rands; R E Diehl; R A Mumford; E E Slater; I S Sigal; M G Caron; R J Lefkowitz; C D Strader
Journal:  Nature       Date:  1986 May 1-7       Impact factor: 49.962

4.  cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

Authors:  B K Kobilka; R A Dixon; T Frielle; H G Dohlman; M A Bolanowski; I S Sigal; T L Yang-Feng; U Francke; M G Caron; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

5.  Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence.

Authors:  T Kubo; A Maeda; K Sugimoto; I Akiba; A Mikami; H Takahashi; T Haga; K Haga; A Ichiyama; K Kangawa
Journal:  FEBS Lett       Date:  1986-12-15       Impact factor: 4.124

6.  Path of the polypeptide in bacteriorhodopsin.

Authors:  D M Engelman; R Henderson; A D McLachlan; B A Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

7.  Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol.

Authors:  C Petrongolo; J Tomasi
Journal:  J Med Chem       Date:  1974-05       Impact factor: 7.446

8.  Identification of a family of muscarinic acetylcholine receptor genes.

Authors:  T I Bonner; N J Buckley; A C Young; M R Brann
Journal:  Science       Date:  1987-07-31       Impact factor: 47.728

9.  Chemical modification of alpha 2-adrenoceptors. Possible role for tyrosine in the ligand binding site.

Authors:  H Nakata; J W Regan; R J Lefkowitz
Journal:  Biochem Pharmacol       Date:  1986-11-15       Impact factor: 5.858

10.  Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

Authors:  J W Regan; T S Kobilka; T L Yang-Feng; M G Caron; R J Lefkowitz; B K Kobilka
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205
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