| Literature DB >> 25554221 |
Jun Zhang1, Shuangmei Liu1, Baohua Xu2, Guodong Li1, Guilin Li1, An Huang3, Bing Wu1, Lichao Peng1, Miaomiao Song1, Qiuyu Xie4, Weijian Lin4, Wei Xie4, Shiyao Wen4, Zhedong Zhang4, Xiaoling Xu5, Shangdong Liang6.
Abstract
After the myocardial ischemia, injured myocardial tissues released large quantity of ATP, which activated P2X3 receptor in superior cervical ganglia and made the SCG postganglionic neurons excited. Excitatory of sympathetic postganglionic efferent neurons increased the blood pressure and heart rates, which aggravated the myocardial ischemic injury. Baicalin has anti-inflammatory and anti-oxidant properties. Our study showed that baicalin reduced the incremental concentration of serum CK-MB, cTn-T, epinephrine and ATP, decreased the up-regulated expression levels of P2X3 mRNA and protein in SCG after MI, and then inhibited the sympathetic excitatory activity triggered by MI injury. These results indicated that baicalin acted on P2X3 receptor was involved in the transmission of sympathetic excitation after the myocardial ischemic injury. Baicalin might decrease sympathetic activity via inhibiting P2X3 receptor in rat SCG to protect the myocardium.Entities:
Keywords: Baicalin; P2X(3) receptor; Superior cervical ganglia; Sympathetic activity
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Year: 2014 PMID： 25554221 DOI： 10.1016/j.autneu.2014.12.001
Source DB: PubMed Journal: Auton Neurosci ISSN： 1566-0702 Impact factor: 3.145